Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.49 |
| ▸ | CCR9 | P51686 | 2/20 | 0.49 |
| ▸ | TNKS | O95271 | 2/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18338261 | 0.89 | MEN1 (0.50) | CCR2CCR9TNKSTNKS2KDM4E | |
| SCHEMBL18345113 | 0.84 | CCR2 (0.48) | CCR2CCR9MTNR1AMTNR1BKDM4E | |
| SCHEMBL28211206 | 0.84 | ALDH1A1 (0.50) | CCR2GPR35KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL18338142 | 0.80 | TP53 (0.58) | MTNR1AMTNR1BKDM4EALDH1A1HSD17B10 | |
| SCHEMBL14693726 | 0.78 | CCR2 (0.77) | CCR2CCR9GPR35MTNR1AMTNR1B | |
| SCHEMBL21975561 | 0.77 | MEN1 (0.53) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL18247515 | 0.77 | CCR2 (0.64) | CCR2CCR9GPR35MTNR1AMTNR1B | |
| SCHEMBL18345011 | 0.75 | TSHR (0.50) | GPR35ALDH1A1SMN1; SMN2MAPTTSHR | |
| SCHEMBL18338241 | 0.75 | POLB (0.57) | CCR9KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL12352768 | 0.75 | CCR2 (0.61) | CCR2CCR9MTNR1AMTNR1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313846-A1 | THIENOPYRROLE COMPOUNDS AND USES THEREOF AS INHIBITORS OF OPLOPHORUS-DERIVED LUCIFERASES | Promega Corporation (US) | 2018-05-02 | — | — | EP | disclosed |
| WO-2016210294-A1 | THIENOPYRROLE COMPOUNDS AND USES THEREOF AS INHIBITORS OF OPLOPHORUS-DERIVED LUCIFERASES | PROMEGA CORPORATION (US) | 2016-12-29 | — | — | WO | disclosed |