Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16917651 | 0.86 | NR1H4 (0.74) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4758952 | 0.83 | NR1H4 (0.66) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4758605 | 0.82 | NR1H4 (0.61) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4526416 | 0.81 | NR1H4 (0.86) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4309430 | 0.80 | NR1H4 (0.76) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL688640 | 0.80 | NR1H4 (0.76) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4300482 | 0.79 | NR1H4 (0.78) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL19273439 | 0.78 | NR1H4 (0.49) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4759182 | 0.77 | NR1H4 (0.55) | NR1H4ESR1NR3C1PGRNR3C2 | |
| SCHEMBL4520715 | 0.76 | NR1H4 (0.84) | NR1H4ESR1NR3C1PGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180000768-A1 | INTESTINAL FXR AGONISM ENHANCES GLP-1 SIGNALING TO RESTORE PANCREATIC BETA CELL FUNCTIONS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2018-01-04 | — | — | US | disclosed |
| US-20160376279-A1 | FXR AGONISTS AND METHODS FOR MAKING AND USING | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2016-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180000768-A1 | INTESTINAL FXR AGONISM ENHANCES GLP-1 SIGNALING TO RESTORE PANCREATIC BETA CELL FUNCTIONS | GLP1R, GIPR, FXR1 | NR1H4 10/4885ESR1 1524/4885NR3C1 382/4885 |
| US-20160376279-A1 | FXR AGONISTS AND METHODS FOR MAKING AND USING | NR1H4, FXR2, FXR1 | NR1H4 1/4885ESR1 658/4885NR3C1 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.