FXR2

RNA-binding protein FXR2 · P51116 · FXR2 on Sugi Atlas →

3,202 patent compounds predicted against FXR2, 2,886 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Px-102 (SCHEMBL1164533)	1.00	1/20
Px-102 (SCHEMBL17087850)	1.00	1/20
Px-102 (SCHEMBL17087854)	1.00	1/20
Px-102 (SCHEMBL17087855)	1.00	1/20
Px-102 (SCHEMBL17087856)	1.00	1/20
Px-102 (SCHEMBL12098287)	0.91	1/20
SCHEMBL18724886	0.87	1/20
SCHEMBL1163928	0.86	1/20
SCHEMBL12168956	0.86	1/20
SCHEMBL12879039	0.86	1/20
SCHEMBL17087847	0.86	1/20
SCHEMBL17087849	0.86	1/20
SCHEMBL17087853	0.86	1/20
Px-102 (SCHEMBL17079090)	0.85	1/20
Px-102 (SCHEMBL18337964)	0.85	1/20
Px-102 (SCHEMBL18337986)	0.85	1/20
Px-102 (SCHEMBL18337988)	0.85	1/20
Px-102 (SCHEMBL18347363)	0.85	1/20
SCHEMBL12168858	0.84	1/20
SCHEMBL1164165	0.83	1/20

Clinical trials — most relevant to FXR2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Obeticholic Acid Among Chronic HBV Patients with Hepatic Steatosis : Clinical and Portal Doppler Outcomes	PHASE3	NOT_YET_RECRUITING
Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus	PHASE3	COMPLETED
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis	PHASE2	ACTIVE_NOT_RECRUITING
Obeticholic Acid in Bile Acid Diarrhoea	PHASE2	COMPLETED
Cholic Acid for Hepatic Steatosis in Lipodystrophy	PHASE2	COMPLETED
Fibrates in Pediatric Cholestasis	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Ursodiol, Combination Chemotherapy, and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer	PHASE1	COMPLETED
An Open-Label Trial of Donepezil in Fragile X Syndrome	PHASE1	COMPLETED
Effects of FXR Activation on Hepatic Lipid and Glucose Metabolism	EARLY_PHASE1	COMPLETED
FGF19 in Obstructive Cholestasis: Unveil the Signal	nan	UNKNOWN
Role of Obeticholic Acid in the Patients of NAFLD With Raised ALT	nan	COMPLETED
Mechanisms of Glucose Lowering Effect of Colesevelam HCl	nan	COMPLETED
The Effect of Sleeve Gastrectomy on Post-prandial Serum Bile Acids	nan	COMPLETED
Effects of Colesevelam HCl On Bile Acid Kinetics	nan	COMPLETED
The Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus	nan	COMPLETED
Mapping Disease Pathways for Biliary Atresia	nan	RECRUITING
Association Between Luminal Bile Salt Content and Duodenal Mucosal Integrity in Functional Dyspepsia	nan	COMPLETED
Genetic-specific Effects of Fructose on Liver Lipogenesis	nan	COMPLETED
Metabolic Syndrome, Bile Acids, Hepatocellular Carcinoma and Cholangiocarcinoma	nan	COMPLETED
Gut Microbiota and Modulation of Liver Damage in NAFLD	nan	COMPLETED
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy	nan	NOT_YET_RECRUITING
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Changes in the Hepatobiliary System in Patients With Primary Biliary Cholangitis Before and After Treatment.	nan	ACTIVE_NOT_RECRUITING
DEFINING THE GENETIC DRIVERS OF ADULT-ONSET CHOLESTATIC LIVER DISEASE	nan	RECRUITING
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Acute Fatty Acid Intervention Study (AFAST)	nan	COMPLETED
Micro RNA Levels in NAFLD	nan	UNKNOWN
Evaluation of MicroRNA Expression in Blood and Cytology for Detecting Barrett's Esophagus and Associated Neoplasia	nan	UNKNOWN
Protocol for the Assessment of Variability in Histology and Gene Expression in Bariatric Surgery Patients.	nan	COMPLETED
Effect of Bariatric Surgery on Bile Acid Homeostasis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a FXR2 binder may also engage these)

Protein	Name	Similarity
Q9WVR4	—	1.000	Q9WVR4 →
P51115	—	0.997	P51115 →
Q61584	—	0.997	Q61584 →
Q7ZTQ5	—	0.996	Q7ZTQ5 →
Q5BJ56	—	0.996	Q5BJ56 →
F1QLR3	—	0.994	F1QLR3 →
Q5XI81	—	0.994	Q5XI81 →
O70523	—	0.992	O70523 →
Q2TBT7	—	0.990	Q2TBT7 →
P35922	—	0.989	P35922 →
FXR1	RNA-binding protein FXR1	0.988	landscape →
Q6GLC9	—	0.988	Q6GLC9 →
Q06787	—	0.987	Q06787 →
Q80WE1	—	0.987	Q80WE1 →
Q5R9B4	—	0.985	Q5R9B4 →
P98175	—	0.983	P98175 →
P70166	—	0.983	P70166 →
Q9NFU0	—	0.983	Q9NFU0 →
Q99KG3	—	0.982	Q99KG3 →
Q8TEW0	—	0.982	Q8TEW0 →
SMARCC2	SWI/SNF complex subunit SMARCC2	0.982	landscape →
Q9DDY9	—	0.982	Q9DDY9 →
Q0V898	—	0.982	Q0V898 →
P0C279	—	0.981	P0C279 →
Q91572	—	0.981	Q91572 →
Q09YM8	—	0.981	Q09YM8 →
Q9Z136	—	0.981	Q9Z136 →
Q6ZPS6	—	0.981	Q6ZPS6 →
Q9H694	—	0.981	Q9H694 →
Q9ULJ8	—	0.981	Q9ULJ8 →