SCHEMBL18347449

SCHEMBL18347449

N#Cc1ccc(-n2c3ccc(C#N)cc3c3cccc(-c4ccccc4-c4ccccc4-n4c5ccccc5c5cc(C#N)ccc54)c32)cc1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 2/20 0.36
USP14 P54578 3/20 0.34
DUSP3 P51452 1/20 0.34
IDO1 P14902 1/20 0.34
TDO2 P48775 1/20 0.34
RORC P51449 6/20 0.34
KDM1A O60341 1/20 0.34
RARG P13631 1/20 0.33
RPS6KB1 P23443 1/20 0.33
GSK3B P49841 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
TDP2 O95551 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18347471 1.00 PTGER4 (0.36) PTGER4USP14DUSP3IDO1TDO2
SCHEMBL18347419 1.00 PTGER4 (0.36) PTGER4USP14DUSP3IDO1TDO2
SCHEMBL18347416 0.99 PTGER4 (0.37) PTGER4USP14DUSP3IDO1TDO2
SCHEMBL18347447 0.94 DUSP3 (0.37) PTGER4USP14DUSP3IDO1TDO2
SCHEMBL18347417 0.93 DUSP3 (0.38) PTGER4USP14DUSP3IDO1TDO2
SCHEMBL18347425 0.92 RPS6KB1 (0.37) PTGER4DUSP3RPS6KB1KDM4ETDP2
SCHEMBL18347470 0.92 RPS6KB1 (0.37) PTGER4DUSP3RPS6KB1KDM4ETDP2
SCHEMBL18347472 0.92 RPS6KB1 (0.37) PTGER4DUSP3RPS6KB1KDM4ETDP2
SCHEMBL18348368 0.92 KDM4E (0.41) PTGER4USP14DUSP3IDO1TDO2
SCHEMBL18348384 0.92 KDM4E (0.41) PTGER4USP14DUSP3IDO1TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160380210-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2016-12-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160380210-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME CRY1, CRY2, CCNT1 PTGER4 473/4885USP14 3765/4885DUSP3 4848/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.