Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16964114 | 0.92 | LMNA (0.42) | SYKMAPK1HTTTP53MAPT | |
| SCHEMBL16964115 | 0.92 | LMNA (0.42) | SYKMAPK1HTTTP53MAPT | |
| SCHEMBL12103452 | 0.89 | TP53 (0.51) | SYKMAPK1HTTTP53MAPT | |
| SCHEMBL16964208 | 0.88 | LMNA (0.45) | SYKMAPK1HTTTP53MAPT | |
| SCHEMBL16964209 | 0.88 | LMNA (0.45) | SYKMAPK1HTTTP53MAPT | |
| SCHEMBL12103419 | 0.85 | MAPT (0.39) | SYKMAPK1HTTTP53MAPT | |
| SCHEMBL12106816 | 0.84 | MAPT (0.41) | SYKMAPK1HTTTP53MAPT | |
| SCHEMBL12103798 | 0.84 | TP53 (0.39) | SYKMAPK1HTTTP53MAPT | |
| SCHEMBL1939342 | 0.83 | SYK (0.55) | SYKMAPK1HTTTP53MAPT | |
| SCHEMBL12106915 | 0.83 | TP53 (0.40) | SYKMAPK1HTTTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900639-B1 | BICYCLIC DIHYDROPYRIDONE KINASE INHIBITORS | PORTOLA PHARM INC (US) | 2017-08-16 | — | — | EP | disclosed |
| US-9533986-B2 | Bicyclic dihydropyridone kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2017-01-03 | — | — | US | disclosed |