SCHEMBL1835535

SCHEMBL1835535

CSC[C@H](C)NC(=O)c1ccccc1C(F)(F)F

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.54
GAA P10253 1/20 0.54
CTSS P25774 6/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
CTSK P43235 2/20 0.45
F2R P25116 1/20 0.44
PTPRC P08575 1/20 0.43
KCNK3 O14649 3/20 0.43
KCNK9 Q9NPC2 3/20 0.43
POLB P06746 1/20 0.43
PTGS1 P23219 1/20 0.43
RECQL P46063 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24567557 0.85 MEN1 (0.65) LMNAGAACTSSMEN1KMT2A
SCHEMBL2161352 0.83 CTSS (0.43) LMNAGAACTSSMEN1KMT2A
SCHEMBL13761361 0.82 LMNA (0.64) LMNAGAACTSSCTSKF2R
SCHEMBL2161769 0.80 KCNK3 (0.53) MEN1KMT2AF2RKCNK3KCNK9
SCHEMBL24571391 0.79 LMNA (0.60) LMNAGAACTSSCTSKF2R
SCHEMBL551261 0.79 KMT2A (0.55) LMNAMEN1KMT2APOLB
SCHEMBL4983204 0.78 MEN1 (0.50) LMNAMEN1KMT2APOLB
SCHEMBL28559185 0.78 LMNA (0.58) LMNAGAACTSSCTSKPTPRC
SCHEMBL5423383 0.78 POLB (0.51) GAAMEN1KMT2APOLBRECQL
SCHEMBL2334259 0.78 SMN1; SMN2 (0.53) LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110184188-A1 Insecticidal Benzenedicarboxamide Derivative BAYER CROPSCIENCE AG (DE) 2011-07-28 US disclosed
US-20110184188-A1 Insecticidal Benzenedicarboxamide Derivative BAYER CROPSCIENCE AG (DE) 2011-07-28 US disclosed
US-20110184188-A1 Insecticidal Benzenedicarboxamide Derivative BAYER CROPSCIENCE AG (DE) 2011-07-28 US disclosed
EP-2318374-A2 INSECTICIDAL BENZENEDICARBOXAMIDE DERIVATIVE Bayer CropScience AG (DE) 2011-05-11 EP disclosed
WO-2010012442-A2 INSECTICIDAL BENZENEDICARBOXAMIDE DERIVATIVE BAYER CROPSCIENCE AG (DE) 2010-02-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110184188-A1 Insecticidal Benzenedicarboxamide Derivative DDT, BRD9, BCL2A1 LMNA 1928/4885GAA 4457/4885CTSS 2318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.