Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857673 | 0.89 | ROCK2 (0.48) | ROCK2CCR2ROCK1SIGMAR1 | |
| SCHEMBL3953507 | 0.86 | ROCK2 (0.47) | ROCK2KMT2ACCR2ROCK1SIGMAR1 | |
| SCHEMBL3858660 | 0.80 | PDE2A (0.49) | ROCK2CCR2ROCK1 | |
| SCHEMBL3858258 | 0.79 | ROCK2 (0.51) | ROCK2CCR2ROCK1SIGMAR1 | |
| SCHEMBL5639528 | 0.74 | ROCK2 (0.46) | ROCK2CCR2ROCK1MAPK1 | |
| SCHEMBL5642918 | 0.73 | ROCK1 (0.44) | ROCK2POLBCCR2ROCK1 | |
| SCHEMBL5640741 | 0.73 | ROCK1 (0.51) | ROCK2KMT2ACCR2ROCK1MEN1 | |
| SCHEMBL29200978 | 0.72 | KDM4E (0.49) | KMT2AROCK1MEN1 | |
| SCHEMBL3352334 | 0.71 | HTR2A (0.45) | — | |
| SCHEMBL14923489 | 0.71 | CHEK1 (0.47) | KMT2AROCK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2317849-A1 | METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | Inspire Pharmaceuticals, Inc. (US) | 2011-05-11 | — | — | EP | claimed |