Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.51 |
| ▸ | CCR2 | P41597 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3953507 | 0.79 | ROCK2 (0.47) | ROCK2CCR2ROCK1SIGMAR1 | |
| SCHEMBL1835575 | 0.79 | ROCK2 (0.47) | ROCK2CCR2ROCK1SIGMAR1 | |
| SCHEMBL3858660 | 0.77 | PDE2A (0.49) | ROCK2CCR2ROCK1 | |
| SCHEMBL3857673 | 0.76 | ROCK2 (0.48) | ROCK2CCR2ROCK1SIGMAR1 | |
| SCHEMBL13577652 | 0.76 | ROCK2 (0.72) | ROCK2CCR2ROCK1 | |
| SCHEMBL5640699 | 0.72 | ROCK2 (0.47) | ROCK2CCR2ROCK1SIGMAR1 | |
| SCHEMBL5640741 | 0.72 | ROCK1 (0.51) | ROCK2CCR2ROCK1SIGMAR1 | |
| SCHEMBL13293668 | 0.70 | PRMT6 (0.57) | ROCK2 | |
| SCHEMBL29200978 | 0.70 | KDM4E (0.49) | ROCK1 | |
| SCHEMBL3352334 | 0.68 | HTR2A (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099457-A2 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | Inspire Pharmaceuticals, Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008077057-A2 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | INSPIRE PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |