Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1669821 | 1.00 | BRD4 (0.39) | BRD4CREBBPSMN1; SMN2KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL6549729 | 0.98 | BRD4 (0.38) | BRD4CREBBPSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL22791978 | 0.81 | CREBBP (0.58) | BRD4CREBBPSMN1; SMN2KMT2AGAA | |
| SCHEMBL22791631 | 0.81 | CREBBP (0.58) | BRD4CREBBPSMN1; SMN2KMT2AGAA | |
| SCHEMBL21882013 | 0.79 | AKR1B1 (0.39) | BRD4CREBBPSMN1; SMN2KMT2AMAPT | |
| SCHEMBL21882006 | 0.79 | AKR1B1 (0.39) | BRD4CREBBPSMN1; SMN2KMT2AMAPT | |
| SCHEMBL15074412 | 0.79 | BRD4 (0.48) | BRD4CREBBPSMN1; SMN2KMT2ATDP1 | |
| SCHEMBL15052871 | 0.79 | BRD4 (0.48) | BRD4CREBBPSMN1; SMN2KMT2ATDP1 | |
| SCHEMBL21882007 | 0.79 | AKR1B1 (0.39) | BRD4CREBBPSMN1; SMN2KMT2AMAPT | |
| SCHEMBL16123162 | 0.79 | PBRM1 (0.47) | BRD4CREBBPSMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638014-B1 | N-SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF ROR-GAMMA ACTIVITY AND THE TREATMENT OF DISEASES | LYCERA CORP (US) | 2017-01-04 | — | — | EP | disclosed |