Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 3/20 | 0.58 |
| ▸ | BRD4 | O60885 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22791631 | 1.00 | CREBBP (0.58) | CREBBPBRD4SMN1; SMN2HSD17B10GAA | |
| SCHEMBL22791448 | 0.86 | CREBBP (0.46) | CREBBPBRD4SMN1; SMN2HSD17B10GAA | |
| SCHEMBL7345041 | 0.86 | CREBBP (0.46) | CREBBPBRD4SMN1; SMN2HSD17B10GAA | |
| SCHEMBL22570946 | 0.85 | BRD4 (0.45) | CREBBPBRD4SMN1; SMN2HSD17B10GAA | |
| SCHEMBL15074412 | 0.81 | BRD4 (0.48) | CREBBPBRD4SMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL21882013 | 0.81 | AKR1B1 (0.39) | CREBBPBRD4SMN1; SMN2KMT2AMAPT | |
| SCHEMBL16123162 | 0.81 | PBRM1 (0.47) | CREBBPBRD4SMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL21882006 | 0.81 | AKR1B1 (0.39) | CREBBPBRD4SMN1; SMN2KMT2AMAPT | |
| SCHEMBL21882007 | 0.81 | AKR1B1 (0.39) | CREBBPBRD4SMN1; SMN2KMT2AMAPT | |
| SCHEMBL18359152 | 0.81 | BRD4 (0.39) | CREBBPBRD4SMN1; SMN2HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252207-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2020-12-17 | — | — | WO | disclosed |