Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21882007 | 1.00 | AKR1B1 (0.39) | AKR1B1BRD4CREBBPADAMTS5SMN1; SMN2 | |
| SCHEMBL21882013 | 1.00 | AKR1B1 (0.39) | AKR1B1BRD4CREBBPADAMTS5SMN1; SMN2 | |
| SCHEMBL23920083 | 0.86 | AKR1B1 (0.39) | AKR1B1BRD4CREBBPHTR2CAHR | |
| SCHEMBL22955689 | 0.86 | AKR1B1 (0.39) | AKR1B1BRD4CREBBPHTR2CAHR | |
| SCHEMBL23920182 | 0.86 | AKR1B1 (0.39) | AKR1B1BRD4CREBBPHTR2CAHR | |
| SCHEMBL22791631 | 0.81 | CREBBP (0.58) | AKR1B1BRD4CREBBPSMN1; SMN2NISCH | |
| SCHEMBL22791978 | 0.81 | CREBBP (0.58) | AKR1B1BRD4CREBBPSMN1; SMN2NISCH | |
| SCHEMBL23920549 | 0.79 | AHR (0.39) | ADAMTS5SMN1; SMN2HTR2CAHRNISCH | |
| SCHEMBL21621076 | 0.79 | AHR (0.39) | ADAMTS5SMN1; SMN2HTR2CAHRNISCH | |
| SCHEMBL21882009 | 0.79 | ADAMTS5 (0.38) | ADAMTS5HTR2CAHRNISCHADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230042881-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2023-02-09 | — | — | US | disclosed |
| US-11318133-B2 | Modulators of integrated stress response pathway | Praxis Biotech LLC (US) | 2022-05-03 | — | — | US | disclosed |
| US-11166942-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2021-11-09 | — | — | US | disclosed |
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2021-10-14 | — | — | US | disclosed |
| WO-2020252205-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2020-12-17 | — | — | WO | disclosed |
| US-20200390759-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-12-17 | — | — | US | disclosed |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230042881-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, ATF1, DDIT3 | AKR1B1 2320/4885BRD4 2132/4885CREBBP 37/4885 |
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | AKR1B1 2292/4885BRD4 1541/4885CREBBP 101/4885 |
| US-11166942-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | AKR1B1 2292/4885BRD4 1541/4885CREBBP 101/4885 |
| US-20200390759-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, ATF1, DDIT3 | AKR1B1 2320/4885BRD4 2132/4885CREBBP 37/4885 |
| US-11318133-B2 | Modulators of integrated stress response pathway | ATF4, ATF1, DDIT3 | AKR1B1 2320/4885BRD4 2132/4885CREBBP 37/4885 |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | AKR1B1 2292/4885BRD4 1541/4885CREBBP 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.