Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992220 | 0.86 | ALDH1A1 (0.43) | POLBTSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18359283 | 0.76 | SMN1; SMN2 (0.47) | POLBSMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL2862025 | 0.76 | TSHR (0.55) | IKBKBPOLBL3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL2099625 | 0.76 | ALDH1A1 (0.42) | L3MBTL1SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL22118930 | 0.75 | TSHR (0.34) | POLBL3MBTL1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL5159269 | 0.74 | POLB (0.40) | POLBL3MBTL1TSHR | |
| SCHEMBL15651754 | 0.72 | POLB (0.50) | POLBL3MBTL1TSHRALDH1A1KDM4E | |
| Bromide SCHEMBL5382898 | 0.72 | POLB (0.39) | POLBL3MBTL1TSHR | |
| SCHEMBL30420448 | 0.70 | HCAR3 (0.38) | IKBKBL3MBTL1NR3C2ALDH1A1KDM4E | |
| SCHEMBL15651375 | 0.70 | KMT2A (0.43) | POLBTSHRSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004133-A1 | IRAK INHIBITORS AND USES THEREOF | NIMBUS IRIS, INC. (US) | 2017-01-05 | — | — | WO | disclosed |