Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 10/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22609430 | 0.76 | ADORA3 (0.33) | MAPTALDH1A1KDM4EADORA3 | |
| SCHEMBL12725096 | 0.75 | HTT (0.33) | HTTSMN1; SMN2ALDH1A1KDM4ENPC1 | |
| SCHEMBL17482117 | 0.70 | TP53 (0.31) | TP53HTTSMN1; SMN2MAPTPOLB | |
| SCHEMBL18359322 | 0.68 | TP53 (0.38) | TP53MAPTPOLBMAT2AADORA3 | |
| SCHEMBL23399524 | 0.66 | — | — | |
| SCHEMBL18083200 | 0.63 | L3MBTL1 (0.47) | HTTSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL20155691 | 0.62 | NPC1 (0.40) | HTTSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL162535 | 0.62 | ADORA3 (0.36) | HTTSMN1; SMN2ALDH1A1KDM4ENPC1 | |
| SCHEMBL28714420 | 0.61 | NOTUM (0.43) | HTTSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL12725097 | 0.61 | ENPP1 (0.36) | TP53MAPTALDH1A1NPC1MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004133-A1 | IRAK INHIBITORS AND USES THEREOF | NIMBUS IRIS, INC. (US) | 2017-01-05 | — | — | WO | disclosed |