Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 14/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18360641 | 0.80 | EPHX2 (0.38) | EPHX2KCNH2CACNA1C | |
| SCHEMBL18360575 | 0.78 | MAPK1 (0.36) | EPHX2 | |
| SCHEMBL18360635 | 0.78 | MAPK1 (0.42) | EPHX2KCNH2 | |
| SCHEMBL18360686 | 0.75 | KMT2A (0.49) | — | |
| SCHEMBL15065309 | 0.75 | BRD4 (0.50) | — | |
| SCHEMBL15065310 | 0.75 | BRD4 (0.50) | — | |
| SCHEMBL15065307 | 0.75 | BRD4 (0.50) | — | |
| SCHEMBL18360581 | 0.75 | — | — | |
| SCHEMBL18360589 | 0.74 | — | — | |
| SCHEMBL18360675 | 0.74 | MAOA (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2615916-B1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-01-04 | — | — | EP | disclosed |