Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 7/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2547154 | 0.99 | PCSK9 (0.36) | PCSK9PKMMAPTNPC1RAB9A | |
| SCHEMBL1836150 | 0.85 | MAPT (0.42) | PKMMAPTNPC1RAB9AOPRK1 | |
| Hydrochloric Acid SCHEMBL2547151 | 0.84 | MAPT (0.42) | PKMMAPTNPC1RAB9AOPRK1 | |
| SCHEMBL2538170 | 0.84 | PIK3CA (0.49) | NPC1RAB9ASMN1; SMN2HTTPIK3CA | |
| SCHEMBL1829720 | 0.83 | RAB9A (0.48) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL1828695 | 0.83 | MAPT (0.42) | PKMMAPTNPC1RAB9AOPRK1 | |
| SCHEMBL2540705 | 0.83 | RAB9A (0.42) | PKMMAPTNPC1RAB9AOPRK1 | |
| SCHEMBL1841257 | 0.81 | CASP3 (0.50) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2547101 | 0.81 | LRRK2 (0.52) | PKMMAPTNPC1RAB9AOPRK1 | |
| SCHEMBL2547102 | 0.80 | NPC1 (0.46) | PKMMAPTNPC1RAB9AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318414-A2 | IMIDAZO [1,2-A] PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND USE AS MET INHIBITORS | Sanofi-Aventis (FR) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010007318-A2 | NOVEL IMIDAZO[1,2-A]PYRIMIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2010-01-21 | — | — | WO | disclosed |