Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thioguanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.66 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.66 |
| ▸ | CDK2 | P24941 | 12/20 | 0.61 |
| ▸ | DPP4 | P27487 | 1/20 | 0.61 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 12/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 12/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.51 |
| ▸ | MGMT | P16455 | 5/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioguanine SCHEMBL9153902 | 0.86 | PDPK1 (0.63) | PDPK1GDACDK2DPP4MAP3K5 | |
| SCHEMBL1275417 | 0.79 | PDPK1 (0.44) | PDPK1GDACDK2DPP4MAP3K5 | |
| 2,6-Diaminopurine SCHEMBL24053 | 0.79 | PDPK1 (1.00) | PDPK1GDACDK2DPP4MAP3K5 | |
| 2,6-Diaminopurine SCHEMBL27891733 | 0.78 | PDPK1 (0.96) | PDPK1GDACDK2DPP4MAP3K5 | |
| 2,6-Diaminopurine SCHEMBL8757979 | 0.78 | PDPK1 (0.96) | PDPK1GDACDK2DPP4MAP3K5 | |
| 2,6-Diaminopurine SCHEMBL28206545 | 0.78 | PDPK1 (0.96) | PDPK1GDACDK2DPP4MAP3K5 | |
| SCHEMBL833645 | 0.76 | GDA (0.41) | PDPK1GDACDK2DPP4MAP3K5 | |
| 6-Chloroguanine SCHEMBL64059 | 0.76 | DPP4 (1.00) | PDPK1GDACDK2DPP4MAP3K5 | |
| SCHEMBL16146853 | 0.76 | PDPK1 (0.41) | PDPK1GDACDK2DPP4MAP3K5 | |
| SCHEMBL135690 | 0.76 | CDK2 (1.00) | PDPK1GDACDK2DPP4MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 883 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118931997-A | Method for synthesizing adenosine and/or uridine by three-enzyme cascade catalysis | 上海飞腾医药科技有限公司 | 2024-11-12 | — | — | CN | claimed |
| CN-118525862-A | Gold nanoparticle and preparation method and application thereof | 佛山鲲鹏现代农业研究院 | 2024-08-23 | — | — | CN | claimed |
| CN-116333706-B | Corrosion inhibitor system for acidification with temperature resistance of 180 ℃ and preparation method and application thereof | 中国石油天然气股份有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-117384259-A | Cell penetrating peptides based on influenza virus M2 proteins | 中国医学科学院基础医学研究所 | 2024-01-12 | — | — | CN | claimed |
| CN-112912386-B | Cell penetrating peptides based on influenza virus M2 proteins | 中国医学科学院基础医学研究所 | 2023-10-20 | — | — | CN | claimed |
| CN-116333706-A | Corrosion inhibitor system for acidification with temperature resistance of 180 ℃ and preparation method and application thereof | 中国石油天然气股份有限公司 | 2023-06-27 | — | — | CN | claimed |
| US-20220169680-A1 | CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN | INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2022-06-02 | — | — | US | claimed |
| CN-107412780-B | Antibacterial agent based on gold nanoparticle surface modified nitrogen heterocyclic micromolecules | 国家纳米科学中心 | 2022-04-15 | — | — | CN | claimed |
| EP-3912989-A1 | CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN | Institute of Basic Medical Sciences Chinese Academy of Medical Sciences (CN) | 2021-11-24 | — | — | EP | claimed |
| CN-110408968-B | Chemical plating solution and preparation method and application thereof | 中国科学院深圳先进技术研究院 | 2021-11-05 | — | — | CN | claimed |
| WO-1994015622-A1 | NUCLEOSIDE DERIVATIVES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | CAMBRIDGE NEUROSCIENCE (US) | 1994-07-21 | — | — | WO | claimed |
| US-5225550-A | PROCESS FOR THE PREPARATION OF SUBSTITUTED ACYCLIC NUCLEOSIDES, AND INTERMEDIATES OCCURRING THEREIN | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-06 | — | — | US | claimed |
| EP-0540686-A4 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES | US COMMERCE (US) | 1993-05-26 | — | — | EP | claimed |
| EP-0540686-A1 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES. | US COMMERCE (US) | 1993-05-12 | — | — | EP | claimed |
| US-5126439-A | Complementary purines and pyrimidines | TEMPLE UNIVERSITY (US) | 1992-06-30 | — | — | US | claimed |
| WO-1992001700-A1 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) | 1992-02-06 | — | — | WO | claimed |
| EP-0464511-A2 | Process for the preparation of acyclic, substituted nucleosides and its intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-01-08 | — | — | EP | claimed |
| WO-1991006645-A1 | PROCESS FOR MUTAGENESIS OF DOUBLE-STRAND CIRCULAR DNA | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 1991-05-16 | — | — | WO | claimed |
| EP-0098122-B1 | PROCESSES FOR PRODUCING L-PROLINE BY FERMENTATION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-05-31 | — | — | EP | claimed |
| EP-0098122-A2 | Processes for producing L-proline by fermentation | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1984-01-11 | — | — | EP | claimed |