6-Chloroguanine

6-Chloroguanine

SCHEMBL64059

Nc1nc(Cl)c2[nH]cnc2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 1.00
PDPK1 O15530 1/20 0.66
GDA Q9Y2T3 1/20 0.66
CDK2 P24941 7/20 0.61
MAP3K5 Q99683 1/20 0.56
CDK1 P06493 6/20 0.51
CCNB1 P14635 6/20 0.51
CCNA2 P20248 6/20 0.51
CCNA1 P78396 6/20 0.51
MGMT P16455 4/20 0.50
BRAF P15056 2/20 0.50
PNP P00491 1/20 0.50
PIN1 Q13526 2/20 0.49
ADORA2A P29274 1/20 0.49
ADORA1 P30542 1/20 0.49
HRH4 Q9H3N8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
6-Chloroguanine SCHEMBL9183931 0.98 DPP4 (0.96) DPP4PDPK1GDACDK2MAP3K5
6-Chloroguanine SCHEMBL8715991 0.98 DPP4 (0.96) DPP4PDPK1GDACDK2MAP3K5
6-Chloroguanine SCHEMBL28284949 0.98 DPP4 (0.96) DPP4PDPK1GDACDK2MAP3K5
6-Chloroguanine SCHEMBL9079950 0.98 DPP4 (0.96) DPP4PDPK1GDACDK2MAP3K5
6-Chloroguanine SCHEMBL18985252 0.88 DPP4 (0.78) DPP4PDPK1GDACDK2MAP3K5
6-Chloroguanine SCHEMBL9424255 0.87 DPP4 (0.76) DPP4PDPK1GDACDK2MAP3K5
6-Chloroguanine SCHEMBL17187927 0.83 DPP4 (0.69) DPP4CDK2CDK1CCNB1CCNA2
6-Chloroguanine SCHEMBL9226302 0.82 DPP4 (0.68) DPP4PDPK1GDACDK2MAP3K5
SCHEMBL37384 0.79 DPP4 (0.66) DPP4PDPK1GDA
2,6-Diaminopurine SCHEMBL24053 0.79 PDPK1 (1.00) DPP4PDPK1GDACDK2MAP3K5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8448 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4696703-A2 NUCLEIC ACID MOLECULES AND USES THEREOF CureVac SE (DE) 2026-02-18 EP claimed
US-20250340868-A1 POLYNUCLEOTIDES ENCODING LINKED ANTIGENS AND USES THEREOF STEMCELL TECHNOLOGIES CANADA INC (CA) 2025-11-06 US claimed
EP-4631970-A2 NUCLEIC ACID MOLECULES AND USES THEREOF CureVac SE (DE) 2025-10-15 EP claimed
EP-4561602-A1 POLYNUCLEOTIDES ENCODING LINKED ANTIGENS AND USES THEREOF Stemcell Technologies Canada Inc. (CA) 2025-06-04 EP claimed
EP-4560315-A2 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2025-05-28 EP claimed
US-20250152737-A1 LIPID NANOPARTICLES COMPRISING VENEZUELAN EQUINE ENCEPHALITIS (VEE) REPLICON AND USES THEREOF STRAND THERAPEUTICS INC. (US) 2025-05-15 US claimed
CN-119977968-A N, N-dibenzyl-N' - (6-chloro-6, 9-dihydro-1H-purin-2-yl) formamidine compound and preparation and application thereof 黄冈鲁班药业股份有限公司 2025-05-13 CN claimed
CN-119977967-A N-methyl-N-benzyl-N' - (6-chloro-6, 9-dihydro-1H-purin-2-yl) formamidine compound and preparation and application thereof 黄冈鲁班药业股份有限公司 2025-05-13 CN claimed
CN-119954809-A Method for separating purine and analogues thereof 杭州中美华东制药有限公司 2025-05-09 CN claimed
CN-119866224-A Polynucleotide encoding a linking antigen and uses thereof 加拿大干细胞技术公司 2025-04-22 CN claimed
EP-0152965-B1 PROCESS FOR PREPARING 2,6-SUBSTITUTED-9-(1,3-DIHYDROXY-2-PROPOXY-MENTHYL)-PURINES AND CERTAIN DERIVATIVES SYNTEX (U.S.A.) INC. (US) 1990-10-24 EP claimed
EP-0391411-A2 3'-Substituted methyl nucleosides as antiviral agents Bristol-Myers Squibb Company (US) 1990-10-10 EP claimed
EP-0366059-A2 Carbocyclic nucleoside analogs BRISTOL-MYERS SQUIBB COMPANY (US) 1990-05-02 EP claimed
CN-1040978-A New New cyclobutane derivative and preparation method thereof NIPPON KAGAKU SANGYO KK (JP) 1990-04-04 CN claimed
EP-0358154-A2 Novel cyclobutane derivative and process for producing same NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1990-03-14 EP claimed
US-4801710-A Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives MERCK & CO., INC. (US) 1989-01-31 US claimed
EP-0260596-A2 2-Amino-6-alkoxy-purins substituted in position 9, process for their preparation, their use and pharmaceutical compositions containing them HOECHST AKTIENGESELLSCHAFT (DE) 1988-03-23 EP claimed
US-4621140-A Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives SYNTEX (U.S.A.) INC. (US) 1986-11-04 US claimed
EP-0184473-A1 Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives MERCK & CO. INC. (US) 1986-06-11 EP claimed
EP-0152965-A2 Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxy-menthyl)-purines and certain derivatives SYNTEX (U.S.A.) INC. (US) 1985-08-28 EP claimed