Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18373453 | 1.00 | SIGMAR1 (0.54) | SIGMAR1MEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL18373409 | 0.92 | SIGMAR1 (0.50) | SIGMAR1CYP3A4 | |
| SCHEMBL18373412 | 0.88 | SIGMAR1 (0.43) | SIGMAR1CYP2D6 | |
| SCHEMBL14653932 | 0.84 | SIGMAR1 (0.55) | SIGMAR1MEN1KMT2A | |
| SCHEMBL18373410 | 0.81 | SIGMAR1 (0.54) | SIGMAR1MEN1KMT2A | |
| SCHEMBL14646740 | 0.81 | SIGMAR1 (0.54) | SIGMAR1MEN1KMT2AKCNH2 | |
| SCHEMBL18373411 | 0.78 | GSK3B (0.36) | SIGMAR1 | |
| SCHEMBL18373438 | 0.76 | SIGMAR1 (0.41) | SIGMAR1MEN1KMT2A | |
| SCHEMBL14646733 | 0.76 | MEN1 (0.45) | SIGMAR1MEN1KMT2AHPGD | |
| SCHEMBL18373452 | 0.75 | SIGMAR1 (0.59) | SIGMAR1MEN1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734524-B1 | PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS, THEIR PREPARATION AND USE AS SIGMA LIGANDS | ESTEVE LABOR DR (ES) | 2017-01-11 | — | — | EP | disclosed |