Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18373432 | 1.00 | SIGMAR1 (0.59) | SIGMAR1KMT2AHTTMEN1ATM | |
| SCHEMBL18373478 | 0.86 | SIGMAR1 (0.59) | SIGMAR1KMT2AHTTATMALDH1A1 | |
| SCHEMBL18373421 | 0.79 | L3MBTL1 (0.40) | SIGMAR1KMT2AHTTMEN1ALPL | |
| SCHEMBL18373476 | 0.78 | SMN1; SMN2 (0.61) | SIGMAR1KMT2AHTTL3MBTL1ALDH1A1 | |
| SCHEMBL18373410 | 0.75 | SIGMAR1 (0.54) | SIGMAR1KMT2AMEN1EGFR | |
| SCHEMBL18373435 | 0.75 | SIGMAR1 (0.54) | SIGMAR1KMT2AMEN1KCNH2 | |
| SCHEMBL14646740 | 0.75 | SIGMAR1 (0.54) | SIGMAR1KMT2AMEN1ALDH1A1KCNH2 | |
| SCHEMBL18373453 | 0.75 | SIGMAR1 (0.54) | SIGMAR1KMT2AMEN1KCNH2 | |
| SCHEMBL14646798 | 0.75 | SIGMAR1 (0.57) | SIGMAR1KMT2AHTTATMALDH1A1 | |
| SCHEMBL14653932 | 0.75 | SIGMAR1 (0.55) | SIGMAR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734524-B1 | PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS, THEIR PREPARATION AND USE AS SIGMA LIGANDS | ESTEVE LABOR DR (ES) | 2017-01-11 | — | — | EP | disclosed |