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Sugi Predict / Compounds / SCHEMBL18375145

SCHEMBL18375145

SCHEMBL18375145

Cc1ccc(S(=O)(=O)c2cc(C(C)(C)CC(C)(C)C)cc(-n3nc4ccccc4n3)c2O)cc1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.46
▸ NPC1 O15118 5/20 0.42
▸ RAB9A P51151 5/20 0.42
▸ LMNA P02545 1/20 0.41
▸ ALDH1A1 P00352 4/20 0.40
▸ KDM4E B2RXH2 3/20 0.40
▸ GAA P10253 2/20 0.40
▸ SMN1; SMN2 Q16637 3/20 0.38
▸ MAPT P10636 2/20 0.38
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ USP2 O75604 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ COMT P21964 4/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ GRM5 P41594 1/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18374935 0.90 POLB (0.43) POLBNPC1RAB9ALMNAALDH1A1
SCHEMBL29895654 0.90 POLB (0.43) POLBNPC1RAB9ALMNAALDH1A1
SCHEMBL28971832 0.86 POLB (0.41) POLBNPC1RAB9ALMNAALDH1A1
SCHEMBL8204058 0.81 NPC1 (0.48) POLBNPC1RAB9ALMNAALDH1A1
SCHEMBL24381713 0.81 POLB (0.38) POLBNPC1RAB9ALMNA
SCHEMBL29895639 0.80 POLB (0.39) POLBNPC1RAB9ALMNAALDH1A1
SCHEMBL105823 0.79 NPC1 (0.43) POLBNPC1RAB9ALMNAALDH1A1
SCHEMBL18375144 0.79 NPC1 (0.40) POLBNPC1RAB9ALMNAALDH1A1
SCHEMBL31438437 0.79 POLB (0.63) POLBNPC1RAB9ALMNAALDH1A1
SCHEMBL31438438 0.79 POLB (0.63) POLBNPC1RAB9ALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3319947-B1 SUBSTITUTED BENZOTRIAZOLE PHENOLS 3M INNOVATIVE PROPERTIES CO (US) 2022-05-04 — — EP disclosed
CN-108026054-B Substituted benzotriazolols 3M创新有限公司 2021-10-15 — — CN disclosed
US-11078419-B2 Substituted benzotriazole phenolate salts and antioxidant compositions formed therefrom 3M INNOVATIVE PROPERTIES COMPANY (US) 2021-08-03 — — US disclosed
US-11053373-B2 Polymeric matrices with ionic additives 3M INNOVATIVE PROPERTIES COMPANY (US) 2021-07-06 — — US disclosed
EP-3320055-B1 SUBSTITUTED BENZOTRIAZOLE PHENOLATE SALTS AND ANTIOXIDANT COMPOSITIONS FORMED THEREFROM 3M INNOVATIVE PROPERTIES CO (US) 2021-03-03 — — EP disclosed
US-10919867-B2 Substituted benzotriazole phenols 3M INNOVATIVE PROPERTIES COMPANY (US) 2021-02-16 — — US disclosed
US-20200172809-A1 SUBSTITUTED BENZOTRIAZOLE PHENOLATE SALTS AND ANTIOXIDANT COMPOSITIONS FORMED THEREFROM 3M INNOVATIVE PROPERTIES CO (US) 2020-06-04 — — US disclosed
US-10669481-B2 Substituted benzotriazole phenolate salts and antioxidant compositions formed therefrom 3M INNOVATIVE PROPERTIES COMPANY (US) 2020-06-02 — — US disclosed
US-20180195000-A1 SUBSTITUTED BENZOTRIAZOLE PHENOLATE SALTS AND ANTIOXIDANT COMPOSITIONS FORMED THEREFROM 3M INNOVATIVE PROPERTIES COMPANY 2018-07-12 — — US disclosed
US-20180195000-A1 SUBSTITUTED BENZOTRIAZOLE PHENOLATE SALTS AND ANTIOXIDANT COMPOSITIONS FORMED THEREFROM 3M INNOVATIVE PROPERTIES COMPANY 2018-07-12 — — US disclosed
US-20180186757-A1 SUBSTITUTED BENZOTRIAZOLE PHENOLS 3M INNOVATIVE PROPERTIES COMPANY 2018-07-05 — — US disclosed
US-20180186757-A1 SUBSTITUTED BENZOTRIAZOLE PHENOLS 3M INNOVATIVE PROPERTIES COMPANY 2018-07-05 — — US disclosed
WO-2017007672-A1 SUBSTITUTED BENZOTRIAZOLE PHENOLS 3M INNOVATIVE PROPERTIES COMPANY (US) 2017-01-12 — — WO disclosed
WO-2017007673-A1 POLYMERIC MATRICES WITH IONIC ADDITIVES 3M INNOVATIVE PROPERTIES COMPANY (US) 2017-01-12 — — WO disclosed
WO-2017007677-A1 SUBSTITUTED BENZOTRIAZOLE PHENOLATE SALTS AND ANTIOXIDANT COMPOSITIONS FORMED THEREFROM 3M INNOVATIVE PROPERTIES COMPANY (US) 2017-01-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180186757-A1 SUBSTITUTED BENZOTRIAZOLE PHENOLS TYR, COMT, TH POLB 924/4885NPC1 4473/4885RAB9A 4635/4885
US-20200172809-A1 SUBSTITUTED BENZOTRIAZOLE PHENOLATE SALTS AND ANTIOXIDANT COMPOSITIONS FORMED THEREFROM COMT, OGFOD1, TYR POLB 889/4885NPC1 4227/4885RAB9A 4875/4885
US-10919867-B2 Substituted benzotriazole phenols TYR, COMT, TH POLB 924/4885NPC1 4473/4885RAB9A 4635/4885
US-10669481-B2 Substituted benzotriazole phenolate salts and antioxidant compositions formed therefrom COMT, OGFOD1, TYR POLB 889/4885NPC1 4227/4885RAB9A 4875/4885
US-11078419-B2 Substituted benzotriazole phenolate salts and antioxidant compositions formed therefrom COMT, OGFOD1, TYR POLB 889/4885NPC1 4227/4885RAB9A 4875/4885
US-20180195000-A1 SUBSTITUTED BENZOTRIAZOLE PHENOLATE SALTS AND ANTIOXIDANT COMPOSITIONS FORMED THEREFROM COMT, OGFOD1, TYR POLB 889/4885NPC1 4227/4885RAB9A 4875/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.