Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
| ▸ | CCND1 | P24385 | 2/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 3/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 7/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29372582 | 0.85 | EGFR (0.68) | EGFRJAK2BRD4FGFR2ALK | |
| SCHEMBL18376602 | 0.85 | EGFR (0.71) | EGFRJAK2BRD4FGFR2ALK | |
| SCHEMBL18376592 | 0.85 | EGFR (0.68) | EGFRJAK2BRD4FGFR2ALK | |
| SCHEMBL29370824 | 0.83 | EGFR (0.66) | EGFRJAK2BRD4FGFR2ALK | |
| SCHEMBL28696412 | 0.83 | EGFR (0.66) | EGFRJAK2BRD4FGFR2ALK | |
| SCHEMBL18376646 | 0.83 | EGFR (0.66) | EGFRJAK2BRD4FGFR2ALK | |
| SCHEMBL29368349 | 0.83 | EGFR (0.66) | EGFRJAK2BRD4FGFR2ALK | |
| SCHEMBL29576513 | 0.82 | EGFR (0.72) | EGFRJAK2BRD4FGFR2ALK | |
| SCHEMBL18376598 | 0.81 | FGFR4 (0.59) | JAK2JAK3PTK2AXLFGFR1 | |
| SCHEMBL29371309 | 0.81 | FGFR4 (0.59) | JAK2JAK3PTK2AXLFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |