Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 16/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | FES | P07332 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | EPHB1 | P54762 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376648 | 0.93 | FGFR2 (0.56) | PTK2FGFR2TTKJAK2BRD4 | |
| SCHEMBL29371829 | 0.93 | FGFR2 (0.56) | PTK2FGFR2TTKJAK2BRD4 | |
| SCHEMBL18377065 | 0.91 | PTK2 (0.55) | PTK2FGFR2TTKJAK2BRD4 | |
| SCHEMBL29368482 | 0.91 | PTK2 (0.55) | PTK2FGFR2TTKJAK2BRD4 | |
| SCHEMBL18376654 | 0.90 | PTK2 (0.52) | PTK2FGFR2TTKJAK2BRD4 | |
| SCHEMBL18376652 | 0.90 | PTK2 (0.52) | PTK2FGFR2TTKJAK2BRD4 | |
| SCHEMBL18377046 | 0.90 | BRD4 (0.63) | TTKJAK2BRD4CDK4JAK3 | |
| SCHEMBL29368354 | 0.89 | CDK4 (0.57) | PTK2TTKJAK2BRD4CDK4 | |
| SCHEMBL18376599 | 0.89 | CDK4 (0.57) | PTK2TTKJAK2BRD4CDK4 | |
| SCHEMBL18376760 | 0.88 | TTK (0.66) | PTK2TTKJAK2BRD4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |