Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | TTK | P33981 | 2/20 | 0.49 |
| ▸ | CDK4 | P11802 | 6/20 | 0.49 |
| ▸ | CCND1 | P24385 | 5/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.48 |
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | JUN | P05412 | 3/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376797 | 0.91 | JAK2 (0.49) | PTK2FGFR2JAK2BRD4TTK | |
| SCHEMBL29371245 | 0.91 | JAK2 (0.49) | PTK2FGFR2JAK2BRD4TTK | |
| SCHEMBL18376647 | 0.90 | PTK2 (0.63) | PTK2FGFR2JAK2BRD4TTK | |
| SCHEMBL29371829 | 0.89 | FGFR2 (0.56) | PTK2FGFR2JAK2BRD4TTK | |
| SCHEMBL18376648 | 0.89 | FGFR2 (0.56) | PTK2FGFR2JAK2BRD4TTK | |
| SCHEMBL18376654 | 0.88 | PTK2 (0.52) | PTK2FGFR2JAK2BRD4TTK | |
| SCHEMBL18377046 | 0.87 | BRD4 (0.63) | JAK2BRD4TTKCDK4CCND1 | |
| SCHEMBL18376599 | 0.87 | CDK4 (0.57) | PTK2JAK2BRD4TTKCDK4 | |
| SCHEMBL29368354 | 0.87 | CDK4 (0.57) | PTK2JAK2BRD4TTKCDK4 | |
| SCHEMBL18376760 | 0.85 | TTK (0.66) | PTK2JAK2BRD4TTKCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |