Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 9/20 | 0.55 |
| ▸ | TTK | P33981 | 3/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | FES | P07332 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | EPHB1 | P54762 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377065 | 1.00 | PTK2 (0.55) | PTK2TTKFGFR2FGFR1FGFR4 | |
| SCHEMBL29370825 | 0.93 | FGFR2 (0.51) | PTK2TTKFGFR2FGFR1JAK2 | |
| SCHEMBL18376603 | 0.93 | FGFR2 (0.51) | PTK2TTKFGFR2FGFR1JAK2 | |
| SCHEMBL18376788 | 0.91 | FGFR2 (0.58) | PTK2TTKFGFR2FGFR1JAK2 | |
| SCHEMBL18376647 | 0.91 | PTK2 (0.63) | PTK2TTKFGFR2FGFR1JAK2 | |
| SCHEMBL18376597 | 0.91 | TTK (0.50) | PTK2TTKFGFR2FGFR1JAK2 | |
| SCHEMBL29370866 | 0.91 | TTK (0.50) | PTK2TTKFGFR2FGFR1JAK2 | |
| SCHEMBL18376797 | 0.91 | JAK2 (0.49) | PTK2TTKFGFR2FGFR1JAK2 | |
| SCHEMBL29371245 | 0.91 | JAK2 (0.49) | PTK2TTKFGFR2FGFR1JAK2 | |
| SCHEMBL18376246 | 0.90 | JAK2 (0.56) | PTK2TTKFGFR1FGFR4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |