Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.48 |
| ▸ | JAK3 | P52333 | 4/20 | 0.48 |
| ▸ | TTK | P33981 | 3/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29371245 | 1.00 | JAK2 (0.49) | JAK2PTK2JAK3TTKFGFR2 | |
| SCHEMBL18376652 | 0.91 | PTK2 (0.52) | JAK2PTK2TTKFGFR2BRD4 | |
| SCHEMBL18377065 | 0.91 | PTK2 (0.55) | JAK2PTK2JAK3TTKFGFR2 | |
| SCHEMBL29368482 | 0.91 | PTK2 (0.55) | JAK2PTK2JAK3TTKFGFR2 | |
| SCHEMBL18376603 | 0.89 | FGFR2 (0.51) | JAK2PTK2JAK3TTKFGFR2 | |
| SCHEMBL18376788 | 0.89 | FGFR2 (0.58) | JAK2PTK2JAK3TTKFGFR2 | |
| SCHEMBL29370825 | 0.89 | FGFR2 (0.51) | JAK2PTK2JAK3TTKFGFR2 | |
| SCHEMBL18376790 | 0.89 | TTK (0.50) | JAK2TTKFGFR2BRD4KDR | |
| SCHEMBL29371949 | 0.89 | TTK (0.50) | JAK2TTKFGFR2BRD4KDR | |
| SCHEMBL18376597 | 0.88 | TTK (0.50) | JAK2PTK2TTKFGFR2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |