Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | JUN | P05412 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | OGA | O60502 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376258 | 0.94 | EGFR (0.61) | EGFRJAK2MAPK10FGFR2BRD4 | |
| SCHEMBL18376726 | 0.93 | JAK2 (0.53) | EGFRJAK2MAPK10FGFR2BRD4 | |
| SCHEMBL18376844 | 0.87 | EGFR (0.65) | EGFRJAK2FGFR2BRD4CDK1 | |
| SCHEMBL18376594 | 0.86 | JAK2 (0.56) | EGFRJAK2MAPK10FGFR2BRD4 | |
| SCHEMBL18376747 | 0.86 | EGFR (0.59) | EGFRJAK2FGFR2BRD4CDK1 | |
| SCHEMBL18377053 | 0.86 | EGFR (0.59) | EGFRJAK2FGFR2BRD4CDK1 | |
| SCHEMBL18376764 | 0.86 | FGFR2 (0.55) | EGFRJAK2MAPK10FGFR2BRD4 | |
| SCHEMBL18376592 | 0.84 | EGFR (0.68) | EGFRJAK2MAPK10FGFR2BRD4 | |
| SCHEMBL29372582 | 0.84 | EGFR (0.68) | EGFRJAK2MAPK10FGFR2BRD4 | |
| SCHEMBL18376259 | 0.83 | JAK3 (0.53) | EGFRJAK2MAPK10FGFR2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |