Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.53 |
| ▸ | JUN | P05412 | 3/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376594 | 0.93 | JAK2 (0.56) | FGFR2MAPK10JUNMAPK8EGFR | |
| SCHEMBL18376258 | 0.91 | EGFR (0.61) | FGFR2MAPK10JUNMAPK8EGFR | |
| SCHEMBL18376726 | 0.87 | JAK2 (0.53) | FGFR2MAPK10JUNMAPK8EGFR | |
| SCHEMBL18376259 | 0.86 | JAK3 (0.53) | FGFR2MAPK10JUNMAPK8EGFR | |
| SCHEMBL18376751 | 0.86 | EGFR (0.58) | FGFR2MAPK10JUNMAPK8EGFR | |
| SCHEMBL29372582 | 0.81 | EGFR (0.68) | FGFR2MAPK10JUNMAPK8EGFR | |
| SCHEMBL18376647 | 0.81 | PTK2 (0.63) | FGFR2PTK2JAK3JAK2BRD4 | |
| SCHEMBL18376592 | 0.81 | EGFR (0.68) | FGFR2MAPK10JUNMAPK8EGFR | |
| SCHEMBL18376783 | 0.79 | JAK2 (0.58) | FGFR2MAPK10MAPK8PTK2JAK3 | |
| SCHEMBL16514480 | 0.78 | FGFR2 (0.84) | FGFR2PTK2EGFRJAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |