Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.51 |
| ▸ | JAK3 | P52333 | 5/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | FES | P07332 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376744 | 0.93 | JAK2 (0.58) | JAK2JAK3PTK2FGFR2FGFR1 | |
| SCHEMBL18376858 | 0.93 | PTK2 (0.51) | JAK2JAK3PTK2FGFR2EGFR | |
| SCHEMBL18376839 | 0.91 | EGFR (0.53) | JAK2JAK3FGFR2EGFRBRD4 | |
| SCHEMBL18376856 | 0.90 | JAK2 (0.51) | JAK2JAK3PTK2FGFR2KDR | |
| SCHEMBL18376849 | 0.90 | JAK2 (0.61) | JAK2JAK3FGFR2MAPK10JAK1 | |
| SCHEMBL18376783 | 0.86 | JAK2 (0.58) | JAK2JAK3PTK2FGFR2MAPK10 | |
| SCHEMBL18377034 | 0.86 | JAK2 (0.60) | JAK2JAK3FGFR2FGFR1KDR | |
| SCHEMBL18376775 | 0.86 | PTK2 (0.51) | JAK2JAK3PTK2FGFR2FGFR1 | |
| SCHEMBL18376832 | 0.84 | JAK2 (0.58) | JAK2JAK3FGFR2EGFRBRD4 | |
| SCHEMBL18376857 | 0.84 | EGFR (0.58) | JAK2JAK3FGFR2EGFRBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |