Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.51 |
| ▸ | JAK3 | P52333 | 7/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376855 | 0.93 | JAK2 (0.58) | JAK2JAK3TBK1MAPK10CDK1 | |
| SCHEMBL18376781 | 0.93 | TBK1 (0.50) | JAK2JAK3TBK1MAPK10CDK1 | |
| SCHEMBL18377059 | 0.91 | CDK1 (0.51) | JAK2JAK3TBK1MAPK10CDK1 | |
| SCHEMBL18376762 | 0.90 | JAK2 (0.51) | JAK2JAK3MAPK10KDRSRC | |
| SCHEMBL18376858 | 0.87 | PTK2 (0.51) | JAK2JAK3TBK1MAPK10FGFR2 | |
| SCHEMBL18376779 | 0.86 | TBK1 (0.50) | JAK2JAK3TBK1MAPK10CDK1 | |
| SCHEMBL18376605 | 0.86 | MAPK10 (0.44) | JAK2JAK3TBK1MAPK10ABL1 | |
| SCHEMBL18377058 | 0.85 | JAK2 (0.59) | JAK2JAK3TBK1MAPK10CDK1 | |
| SCHEMBL18376744 | 0.83 | JAK2 (0.58) | JAK2JAK3TBK1MAPK10KDR | |
| SCHEMBL18376839 | 0.81 | EGFR (0.53) | JAK2JAK3MAPK10CDK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |