Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 9/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376748 | 0.90 | EGFR (0.57) | FGFR2JAK2BRD4EGFRJAK3 | |
| SCHEMBL18376605 | 0.89 | MAPK10 (0.44) | PTK2FGFR2JAK2BRD4JAK3 | |
| SCHEMBL18376845 | 0.89 | HDAC3 (0.55) | PTK2JAK2BRD4FGFR1EGFR | |
| SCHEMBL18376744 | 0.88 | JAK2 (0.58) | PTK2FGFR2JAK2FGFR1KDR | |
| SCHEMBL18376762 | 0.86 | JAK2 (0.51) | PTK2FGFR2JAK2BRD4FGFR1 | |
| SCHEMBL18376763 | 0.85 | PTK2 (0.55) | PTK2FGFR2JAK2BRD4JAK3 | |
| SCHEMBL29205091 | 0.85 | PTK2 (0.55) | PTK2FGFR2JAK2BRD4EGFR | |
| SCHEMBL18377065 | 0.82 | PTK2 (0.55) | PTK2FGFR2JAK2BRD4FGFR1 | |
| SCHEMBL29368482 | 0.82 | PTK2 (0.55) | PTK2FGFR2JAK2BRD4FGFR1 | |
| SCHEMBL18376753 | 0.82 | PTK2 (0.56) | PTK2FGFR2JAK2BRD4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |