Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | JUN | P05412 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29371949 | 1.00 | TTK (0.50) | TTKJAK2BRD4EGFRTLR9 | |
| SCHEMBL18376246 | 0.90 | JAK2 (0.56) | TTKJAK2BRD4EGFRAURKA | |
| SCHEMBL29371334 | 0.90 | JAK2 (0.56) | TTKJAK2BRD4EGFRAURKA | |
| SCHEMBL18376662 | 0.89 | TTK (0.51) | TTKJAK2BRD4EGFRRIPK2 | |
| SCHEMBL18376797 | 0.89 | JAK2 (0.49) | TTKJAK2BRD4EGFRRIPK2 | |
| SCHEMBL29371245 | 0.89 | JAK2 (0.49) | TTKJAK2BRD4EGFRRIPK2 | |
| SCHEMBL18377065 | 0.88 | PTK2 (0.55) | TTKJAK2BRD4EGFRRIPK2 | |
| SCHEMBL29368482 | 0.88 | PTK2 (0.55) | TTKJAK2BRD4EGFRRIPK2 | |
| SCHEMBL18377063 | 0.87 | TTK (0.51) | TTKJAK2BRD4RIPK2CDK4 | |
| SCHEMBL18376252 | 0.87 | TTK (0.65) | TTKJAK2RIPK2CDK4JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |