Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.55 |
| ▸ | JAK3 | P52333 | 5/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 11/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377076 | 0.86 | JAK2 (0.65) | JAK2JAK3PTK2FGFR4FGFR1 | |
| SCHEMBL18376805 | 0.85 | MAPK10 (0.57) | JAK2JAK3PTK2BRD4 | |
| SCHEMBL29371309 | 0.85 | FGFR4 (0.59) | JAK2JAK3PTK2FGFR4FGFR1 | |
| SCHEMBL18376598 | 0.85 | FGFR4 (0.59) | JAK2JAK3PTK2FGFR4FGFR1 | |
| SCHEMBL18376859 | 0.84 | JAK2 (0.49) | JAK2JAK3PTK2BRD4 | |
| SCHEMBL28698465 | 0.83 | FGFR1 (0.50) | JAK2JAK3PTK2FGFR4FGFR1 | |
| SCHEMBL18376806 | 0.83 | JAK2 (0.51) | JAK2JAK3PTK2FGFR4FGFR1 | |
| SCHEMBL29371298 | 0.83 | JAK2 (0.51) | JAK2JAK3PTK2FGFR4FGFR1 | |
| SCHEMBL18376853 | 0.82 | JAK3 (0.58) | JAK2JAK3PTK2AURKA | |
| SCHEMBL18377030 | 0.81 | JAK2 (0.58) | JAK2JAK3PTK2FGFR1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |