Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 12/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 6/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28676614 | 0.87 | JAK2 (0.61) | FGFR1AURKAJAK2JAK3PTK2 | |
| SCHEMBL28681322 | 0.85 | MAPK10 (0.56) | JAK2PTK2BRD4 | |
| SCHEMBL29371309 | 0.84 | FGFR4 (0.59) | FGFR1AXLJAK2JAK3PTK2 | |
| SCHEMBL18376598 | 0.84 | FGFR4 (0.59) | FGFR1AXLJAK2JAK3PTK2 | |
| SCHEMBL18376798 | 0.83 | JAK2 (0.55) | FGFR1AXLAURKBAURKAJAK2 | |
| SCHEMBL28120642 | 0.82 | CDK1 (0.52) | AURKAJAK2JAK3PTK2KDR | |
| SCHEMBL28679014 | 0.81 | JAK2 (0.51) | FGFR1AXLAURKBAURKAJAK2 | |
| SCHEMBL18376789 | 0.80 | BRAF (0.51) | FGFR1AXLJAK2JAK3PTK2 | |
| SCHEMBL18376593 | 0.80 | EGFR (0.61) | FGFR1AXLJAK2JAK3PTK2 | |
| SCHEMBL28686746 | 0.79 | MAPK10 (0.49) | FGFR1AURKAJAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-106316965-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2017-01-11 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
| CN-106316965-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2017-01-11 | — | — | CN | disclosed |