Fluoride

Fluoride

SCHEMBL183785

CCCCCCCC(=O)NCCN(CC)CC.F

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DNM1 Q05193 2/20 0.70
FAAH O00519 5/20 0.64
CASP2 P42575 1/20 0.55
NAAA Q02083 1/20 0.51
EPHX2 P34913 3/20 0.49
SELP P16109 1/20 0.49
HSP90AA1 P07900 1/20 0.48
HDAC3 O15379 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HDAC9 Q9UKV0 1/20 0.48
HDAC5 Q9UQL6 1/20 0.48
CNR1 P21554 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL74821 0.98 DNM1 (0.72) DNM1FAAHCASP2NAAAEPHX2
SCHEMBL8398925 0.98 DNM1 (0.72) DNM1FAAHCASP2NAAAEPHX2
SCHEMBL3005968 0.98 DNM1 (0.72) DNM1FAAHCASP2NAAAEPHX2
SCHEMBL6729860 0.98 DNM1 (0.72) DNM1FAAHCASP2NAAAEPHX2
SCHEMBL76373 0.98 DNM1 (0.72) DNM1FAAHCASP2NAAAEPHX2
SCHEMBL74996 0.98 DNM1 (0.72) DNM1FAAHCASP2NAAAEPHX2
SCHEMBL3411287 0.98 DNM1 (0.72) DNM1FAAHCASP2NAAAEPHX2
SCHEMBL74483 0.98 DNM1 (0.72) DNM1FAAHCASP2NAAAEPHX2
SCHEMBL10964167 0.98 DNM1 (0.72) DNM1FAAHCASP2NAAAEPHX2
Hydrochloric Acid SCHEMBL3121076 0.97 DNM1 (0.70) DNM1FAAHCASP2NAAAEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 288 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230363991-A1 Oral Care Compositions COLGATE-PALMOLIVE COMPANY (US) 2023-11-16 US claimed
EP-4203900-A1 ORAL CARE COMPOSITIONS Colgate-Palmolive Company (US) 2023-07-05 EP claimed
EP-4199887-A1 ORAL CARE COMPOSITIONS Colgate-Palmolive Company (US) 2023-06-28 EP claimed
US-20220401321-A1 Oral Care Compositions COLGATE-PALMOLIVE COMPANY (US) 2022-12-22 US claimed
WO-2022251223-A1 ORAL CARE COMPOSITIONS COLGATE-PALMOLIVE COMPANY (US) 2022-12-01 WO claimed
WO-2022251228-A1 ORAL CARE COMPOSITIONS COLGATE-PALMOLIVE COMPANY (US) 2022-12-01 WO claimed
EP-3370830-B1 ORAL CARE COMPOSITIONS AND METHODS COLGATE PALMOLIVE CO (US) 2020-02-05 EP claimed
EP-3370830-A1 ORAL CARE COMPOSITIONS AND METHODS Colgate-Palmolive Company (US) 2018-09-12 EP claimed
CN-108290061-A ORAL CARE COMPOSITIONS AND METHODS 高露洁-棕榄公司 2018-07-17 CN claimed
WO-2017100265-A1 ORAL CARE COMPOSITIONS AND METHODS COLGATE-PALMOLIVE COMPANY (US) 2017-06-15 WO claimed
US-8568697-B2 High fluoride ion recovery compositions COLGATE-PALMOLIVE COMPANY (US) 2013-10-29 US claimed
US-8506698-B2 Oral compositions and methods COLGATE-PALMOLIVE COMPANY (US) 2013-08-13 US claimed
US-20110033394-A1 ORAL COMPOSITIONS AND METHODS COLGATE-PALMOLIVE COMPANY (US) 2011-02-10 US claimed
EP-2280685-A1 ORAL COMPOSITIONS COMPRISING SHELLAC WAX AND BLEACHED SHELLAC FOR USE IN STOMATOLOGY AND DENTAL CARE Colgate-Palmolive Company (US) 2011-02-09 EP claimed
WO-2009124311-A1 ORAL COMPOSITIONS COMPRISING SHELLAC WAX AND BLEACHED SHELLAC FOR USE IN STOMATOLOGY AND DENTAL CARE COLGATE-PALMOLIVE COMPANY (US) 2009-10-08 WO claimed
US-20090238777-A1 High Fluoride Ion Recovery Compositions COLGATE-PALMOLIVE COMPANY (US) 2009-09-24 US claimed
CN-101484123-A High fluoride ion oral care compositions and methods for maintaining anticaries activity COLGATE PALMOLIVE CO (US) 2009-07-15 CN claimed
EP-2046270-A2 HIGH FLUORIDE ION ORAL CARE COMPOSITION AND METHOD FOR MAINTAINING ANTICARIES ACTIVITY Colgate-Palmolive Company (US) 2009-04-15 EP claimed
WO-2008005688-A2 HIGH FLUORIDE ION ORAL CARE COMPOSITION AND METHOD FOR MAINTAINING ANTICARIES ACTIVITY COLGATE-PALMOLIVE COMPANY (US) 2008-01-10 WO claimed
US-20080003187-A1 High fluoride ion oral care composition and method for maintaining anticaries activity COLGATE-PALMOLIVE COMPANY 2008-01-03 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230363991-A1 Oral Care Compositions DSC1, SLC6A12, OTC DNM1 318/4885FAAH 3976/4885CASP2 1691/4885
US-20220401321-A1 Oral Care Compositions TUBGCP3, TUBGCP4, TUBGCP2 DNM1 394/4885FAAH 4117/4885CASP2 1168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.