Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253585 | 1.00 | NAAA (0.52) | NAAAEPHX1TSHRALDH1A1HTR2C | |
| SCHEMBL4672442 | 1.00 | NAAA (0.52) | NAAAEPHX1TSHRALDH1A1HTR2C | |
| SCHEMBL3880771 | 0.98 | NAAA (0.55) | NAAAEPHX1TSHRALDH1A1HTR2C | |
| SCHEMBL15796773 | 0.98 | NAAA (0.55) | NAAAEPHX1TSHRALDH1A1HTR2C | |
| SCHEMBL5271653 | 0.98 | NAAA (0.55) | NAAAEPHX1TSHRALDH1A1HTR2C | |
| SCHEMBL4206354 | 0.98 | NAAA (0.55) | NAAAEPHX1TSHRALDH1A1HTR2C | |
| SCHEMBL10347198 | 0.98 | NAAA (0.55) | NAAAEPHX1TSHRALDH1A1HTR2C | |
| SCHEMBL4679055 | 0.98 | NAAA (0.55) | NAAAEPHX1TSHRALDH1A1HTR2C | |
| SCHEMBL5271657 | 0.98 | NAAA (0.55) | NAAAEPHX1TSHRALDH1A1HTR2C | |
| SCHEMBL13797804 | 0.98 | NAAA (0.55) | NAAAEPHX1TSHRALDH1A1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386512-B1 | ANTIVIRAL PHOSPHODIAMIDE PRODRUGS OF TENOFOVIR | MERCK SHARP & DOHME LLC (US) | 2023-11-22 | — | — | EP | disclosed |
| US-10745428-B2 | Antiviral phosphodiamide prodrugs of tenofovir | IDENIX PHARMACEUTICALS LLC (US) | 2020-08-18 | — | — | US | disclosed |
| WO-2017007701-A1 | ANTIVIRAL PHOSPHODIAMIDE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745428-B2 | Antiviral phosphodiamide prodrugs of tenofovir | PNP, TYMP, PPA1 | NAAA 285/4885EPHX1 2862/4885TSHR 4347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.