Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18378710 | 0.85 | KDM5A (0.38) | KDM5AHTR2AHTR2CHTR2B | |
| SCHEMBL18378778 | 0.85 | KDM5A (0.38) | KDM5AHTR2AHTR2CHTR2B | |
| SCHEMBL8131168 | 0.85 | KDM5A (0.38) | KDM5AHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8130094 | 0.84 | KDM5A (0.37) | KDM5AHTR2AHTR2CHTR2B | |
| SCHEMBL18377666 | 0.81 | KDM5A (0.32) | KDM5A | |
| SCHEMBL15383467 | 0.81 | CHRNB2 (0.44) | KDM5AHTR2CIRAK4 | |
| SCHEMBL18377698 | 0.81 | KDM5A (0.32) | KDM5A | |
| SCHEMBL18377857 | 0.79 | TLR8 (0.41) | KDM5A | |
| SCHEMBL18164082 | 0.78 | IDO1 (0.40) | KDM5AKCNH2 | |
| SCHEMBL18377658 | 0.78 | IDO1 (0.43) | KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815818-B2 | Cot modulators and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-20170008873-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2017-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008873-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | KDM5A 1081/4885HTR2A 2432/4885HTR2C 3023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.