Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1839027 | 0.93 | NR1H4 (0.37) | NR1H4CXCR1CXCR2 | |
| SCHEMBL1841709 | 0.91 | NR1H4 (0.38) | NR1H4MAPT | |
| SCHEMBL1841219 | 0.90 | NR1H4 (0.38) | NR1H4L3MBTL1 | |
| SCHEMBL1836831 | 0.90 | NR1H4 (0.36) | NR1H4 | |
| SCHEMBL197865 | 0.88 | NR1H4 (0.37) | NR1H4 | |
| SCHEMBL1837938 | 0.87 | NR1H4 (0.34) | NR1H4 | |
| SCHEMBL1841971 | 0.87 | NR1H4 (0.35) | NR1H4 | |
| SCHEMBL1839973 | 0.85 | NR1H4 (0.38) | NR1H4 | |
| SCHEMBL1840968 | 0.85 | NR1H4 (0.38) | NR1H4L3MBTL1 | |
| SCHEMBL1840286 | 0.84 | NR1H4 (0.40) | NR1H4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | claimed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | claimed |
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |