Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.35 |
| ▸ | RBP4 | P02753 | 2/20 | 0.34 |
| ▸ | TTR | P02766 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
| ▸ | RXRG | P48443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841219 | 0.92 | NR1H4 (0.38) | NR1H4LMNAMAPK1HTTRAB9A | |
| SCHEMBL1841709 | 0.87 | NR1H4 (0.38) | NR1H4 | |
| SCHEMBL1838285 | 0.87 | NR1H4 (0.37) | NR1H4 | |
| SCHEMBL1836831 | 0.86 | NR1H4 (0.36) | NR1H4 | |
| SCHEMBL1840968 | 0.85 | NR1H4 (0.38) | NR1H4TTR | |
| SCHEMBL197865 | 0.84 | NR1H4 (0.37) | NR1H4 | |
| SCHEMBL1839027 | 0.81 | NR1H4 (0.37) | NR1H4SCN9A | |
| SCHEMBL1839973 | 0.81 | NR1H4 (0.38) | NR1H4 | |
| SCHEMBL1840602 | 0.81 | NR1H4 (0.36) | NR1H4 | |
| SCHEMBL1840000 | 0.81 | NR1H4 (0.41) | NR1H4RBP4TTRMRGPRX4RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |