Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841219 | 0.93 | NR1H4 (0.38) | NR1H4ALDH1A1L3MBTL1ACKR3 | |
| SCHEMBL1840602 | 0.91 | NR1H4 (0.36) | NR1H4 | |
| SCHEMBL1839027 | 0.90 | NR1H4 (0.37) | NR1H4ACKR3 | |
| SCHEMBL1840258 | 0.88 | NR1H4 (0.36) | NR1H4 | |
| SCHEMBL1841971 | 0.85 | NR1H4 (0.35) | NR1H4TTR | |
| SCHEMBL1836831 | 0.85 | NR1H4 (0.36) | NR1H4 | |
| SCHEMBL1841709 | 0.85 | NR1H4 (0.38) | NR1H4 | |
| SCHEMBL1839157 | 0.85 | NR1H4 (0.37) | NR1H4ALDH1A1 | |
| SCHEMBL1838285 | 0.85 | NR1H4 (0.37) | NR1H4L3MBTL1 | |
| SCHEMBL197865 | 0.82 | NR1H4 (0.37) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |