Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 2/20 | 0.31 |
| ▸ | DDIT3 | P35638 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12089538 | 1.00 | NR1D1 (0.31) | NR1D1DDIT3TDO2 | |
| SCHEMBL17165 | 1.00 | NR1D1 (0.31) | NR1D1DDIT3TDO2 | |
| SCHEMBL18021 | 0.89 | GCK (0.33) | NR1D1DDIT3TDO2 | |
| SCHEMBL12079931 | 0.89 | GCK (0.33) | NR1D1DDIT3TDO2 | |
| SCHEMBL12089837 | 0.89 | GCK (0.33) | NR1D1DDIT3TDO2 | |
| SCHEMBL16510 | 0.79 | GCKR (0.38) | NR1D1DDIT3TDO2 | |
| SCHEMBL17166 | 0.76 | — | — | |
| SCHEMBL17115 | 0.75 | NR1D1 (0.31) | NR1D1TDO2 | |
| SCHEMBL18132 | 0.74 | ALDH1A1 (0.31) | NR1D1 | |
| SCHEMBL12089227 | 0.73 | GCK (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |