Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 3/20 | 0.67 |
| ▸ | PRKCI | P41743 | 7/20 | 0.66 |
| ▸ | CCNK | O75909 | 2/20 | 0.63 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.63 |
| ▸ | IKBKB | O14920 | 3/20 | 0.58 |
| ▸ | CHUK | O15111 | 3/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | LTK | P29376 | 1/20 | 0.58 |
| ▸ | GRK5 | P34947 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20839795 | 0.77 | CCNK (0.65) | NUDT1PRKCICCNKCDK12IKBKB | |
| SCHEMBL20849864 | 0.77 | CCNK (1.00) | NUDT1PRKCICCNKCDK12IKBKB | |
| SCHEMBL14020099 | 0.77 | CCNK (0.58) | NUDT1PRKCICCNKCDK12IKBKB | |
| SCHEMBL31420118 | 0.77 | CCNK (0.58) | NUDT1PRKCICCNKCDK12IKBKB | |
| SCHEMBL1718138 | 0.77 | NUDT1 (0.67) | NUDT1PRKCICCNKCDK12IKBKB | |
| SCHEMBL1717710 | 0.77 | PRKCI (0.61) | NUDT1PRKCICCNKCDK12IKBKB | |
| SCHEMBL2240671 | 0.76 | AURKB (0.71) | NUDT1PRKCICCNKCDK12IKBKB | |
| SCHEMBL2239087 | 0.75 | IKBKB (0.61) | NUDT1PRKCICCNKCDK12IKBKB | |
| SCHEMBL2240782 | 0.75 | AURKB (0.61) | NUDT1PRKCICCNKCDK12IKBKB | |
| SCHEMBL17673079 | 0.75 | IKBKB (0.61) | NUDT1PRKCICCNKCDK12IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011526931-A | — | — | 2011-10-20 | — | — | JP | claimed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | claimed |
| CN-102143746-A | CDK modulators | EXELIXIS INC | 2011-08-03 | — | — | CN | claimed |
| EP-2320895-A2 | CDK MODULATORS | Exelixis, Inc. (US) | 2011-05-18 | — | — | EP | claimed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | claimed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| CN-102143746-A | CDK modulators | EXELIXIS INC | 2011-08-03 | — | — | CN | disclosed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | NUDT1 2054/4885PRKCI 387/4885CCNK 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.