Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | METAP2 | P50579 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1837396 | 0.86 | KDM4E (0.53) | KDM4EHSP90AA1MAPTLMNABRD4 | |
| SCHEMBL15822961 | 0.85 | KDM4E (0.52) | KDM4EHSP90AA1MAPTLMNABRD4 | |
| SCHEMBL6903273 | 0.80 | KDM4E (0.51) | KDM4EHSP90AA1MAPTLMNABRD4 | |
| SCHEMBL1831197 | 0.80 | KDM5A (0.35) | KDM4EHSP90AA1MAPTLMNABRD4 | |
| SCHEMBL27588126 | 0.78 | KDM4E (0.49) | KDM4EHSP90AA1MAPTLMNABRD4 | |
| SCHEMBL28505844 | 0.78 | KDM4E (0.58) | KDM4EHSP90AA1MAPTLMNABRD4 | |
| SCHEMBL6899249 | 0.77 | KDM4E (0.45) | KDM4EHSP90AA1MAPTLMNABRD4 | |
| SCHEMBL6904223 | 0.77 | KDM4E (0.51) | KDM4EHSP90AA1MAPTLMNABRD4 | |
| SCHEMBL12533363 | 0.77 | KDM4E (0.56) | KDM4EHSP90AA1MAPTLMNABRD4 | |
| SCHEMBL28507152 | 0.76 | KDM4E (0.59) | KDM4EHSP90AA1MAPTLMNABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943218-B1 | ALKOXYALKYL SPIROCYCLIC TETRAMIC ACIDS AND TETRONIC ACIDS | BAYER IP GMBH (DE) | 2015-05-06 | — | — | EP | claimed |
| EP-1966135-B1 | 3'-ALKOXY-SPIROCYCLOPENTYL-SUBSTITUTED TETRAMIC AND TETRONIC ACIDS | BAYER CROPSCIENCE AG (DE) | 2013-10-09 | — | — | EP | claimed |
| EP-1761490-B1 | 3'-ALKOXY SPIROCYCLIC TETRAMIC AND TETRONIC ACIDS | BAYER CROPSCIENCE AG (DE) | 2011-09-07 | — | — | EP | claimed |
| EP-1606254-B1 | 2,4,6-PHENYL SUBSTITUTED CYCLIC KETOENOLS | BAYER CROPSCIENCE AG (DE) | 2011-05-11 | — | — | EP | claimed |