⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14421414 | 1.00 | — | — | |
| SCHEMBL183909 | 1.00 | — | — | |
| SCHEMBL16526158 | 0.80 | — | — | |
| SCHEMBL13301079 | 0.77 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL3102738 | 0.77 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL4430295 | 0.72 | — | — | |
| SCHEMBL21118496 | 0.72 | — | — | |
| SCHEMBL21014214 | 0.72 | — | — | |
| SCHEMBL4097383 | 0.72 | — | — | |
| SCHEMBL4430293 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260027089-A1 | MrgprX2 Antagonists for the Treatment of Inflammatory Disorders | DERMIRA INC (US) | 2026-01-29 | — | — | US | disclosed |
| US-12502380-B2 | MrgprX2 antagonists for the treatment of inflammatory disorders | DERMIRA, INC. (US) | 2025-12-23 | — | — | US | disclosed |
| US-20250057816-A1 | MrgprX2 Antagonists for the Treatment of Inflammatory Disorders | DERMIRA, INC. | 2025-02-20 | — | — | US | disclosed |
| US-20230029266-A1 | MrgprX2 Antagonists for the Treatment of Inflammatory Disorders | DERMIRA, INC. | 2023-01-26 | — | — | US | disclosed |
| EP-4054554-A1 | MRGPRX2 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Dermira, Inc (US) | 2022-09-14 | — | — | EP | disclosed |
| CN-114845709-A | MRGPRX2 antagonists for use in treating inflammatory disorders | 德米拉公司 | 2022-08-02 | — | — | CN | disclosed |
| WO-2015049645-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF DASATINIB | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015025172-A1 | 5-ARYL-THIAZOL-2-YL-AMINE COMPOUNDS AND THEIR THERAPEUTIC USE | CHARLES MARK DAVID (GB) | 2015-02-26 | — | — | WO | disclosed |
| US-8841282-B2 | Pyrrolidinone benzenesulfonamide derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-23 | — | — | US | disclosed |
| US-8841282-B2 | Pyrrolidinone benzenesulfonamide derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-23 | — | — | US | disclosed |
| US-20050215795-A1 | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-09-29 | — | — | US | disclosed |
| WO-2005077945-A2 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005076990-A2 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-CARBOXAMIDES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-25 | — | — | WO | disclosed |
| US-20050176965-A1 | Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-08-11 | — | — | US | disclosed |
| EP-1539722-A1 | THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-15 | — | — | EP | disclosed |
| US-20040038990-A1 | Aminothiazole derivatives | HOFFMANN-LA ROCHE INC. | 2004-02-26 | — | — | US | disclosed |
| WO-2004014884-A1 | THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-02-19 | — | — | WO | disclosed |
| EP-0072755-B1 | CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC SANTE (FR) | 1985-08-21 | — | — | EP | disclosed |
| US-4496560-A | ACTIVE AGAINST GRAMPOSITIVE BACTERIA | RHONE-POULENC SANTE (FR) | 1985-01-29 | — | — | US | disclosed |
| EP-0072755-A1 | Cephalosporin derivatives, their preparation and pharmaceutical compositions containing them | RHONE-POULENC SANTE (FR) | 1983-02-23 | — | — | EP | disclosed |