⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183908 | 1.00 | — | — | |
| SCHEMBL14421414 | 1.00 | — | — | |
| SCHEMBL16526158 | 0.80 | — | — | |
| SCHEMBL13301079 | 0.77 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL3102738 | 0.77 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL4430295 | 0.72 | — | — | |
| SCHEMBL21118496 | 0.72 | — | — | |
| SCHEMBL21014214 | 0.72 | — | — | |
| SCHEMBL4097383 | 0.72 | — | — | |
| SCHEMBL4430293 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115845818-B | Lignin grafted N- [ (dimethylamino) methylene ] thiourea type heavy metal adsorbent and preparation method and application thereof | 南京工业大学 | 2024-02-23 | — | — | CN | claimed |
| CN-115845818-A | Lignin grafted N- [ (dimethylamino) methylene ] thiourea heavy metal adsorbent and preparation method and application thereof | 南京工业大学 | 2023-03-28 | — | — | CN | claimed |
| CN-114555568-A | Preparation of 2-chloro-1- (2-chlorothiazol-5-yl) ethanone | 巴斯夫欧洲公司 | 2022-05-27 | — | — | CN | claimed |
| US-20260027089-A1 | MrgprX2 Antagonists for the Treatment of Inflammatory Disorders | DERMIRA INC (US) | 2026-01-29 | — | — | US | disclosed |
| US-12502380-B2 | MrgprX2 antagonists for the treatment of inflammatory disorders | DERMIRA, INC. (US) | 2025-12-23 | — | — | US | disclosed |
| WO-2025130765-A1 | COMPOUNDS, COMPOSITIONS AND METHODS THEREOF | HEPAITECH (BEIJING) BIOPHARMA TECHNOLOGY CO., LTD. (CN) | 2025-06-26 | — | — | WO | disclosed |
| WO-2025066935-A1 | COMPOUNDS, COMPOSITIONS AND METHODS THEREOF | HEPAITECH (BEIJING) BIOPHARMA TECHNOLOGY CO., LTD. (CN) | 2025-04-03 | — | — | WO | disclosed |
| US-20250057816-A1 | MrgprX2 Antagonists for the Treatment of Inflammatory Disorders | DERMIRA, INC. | 2025-02-20 | — | — | US | disclosed |
| CN-114845709-B | MRGPRX2 antagonists for the treatment of inflammatory disorders | 德米拉公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-115845818-B | Lignin grafted N- [ (dimethylamino) methylene ] thiourea type heavy metal adsorbent and preparation method and application thereof | 南京工业大学 | 2024-02-23 | — | — | CN | disclosed |
| CN-115845818-B | Lignin grafted N- [ (dimethylamino) methylene ] thiourea type heavy metal adsorbent and preparation method and application thereof | 南京工业大学 | 2024-02-23 | — | — | CN | disclosed |
| WO-2005077945-A2 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005076990-A2 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-CARBOXAMIDES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-25 | — | — | WO | disclosed |
| US-20050176965-A1 | Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-08-11 | — | — | US | disclosed |
| EP-1539722-A1 | THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-15 | — | — | EP | disclosed |
| US-20040038990-A1 | Aminothiazole derivatives | HOFFMANN-LA ROCHE INC. | 2004-02-26 | — | — | US | disclosed |
| WO-2004014884-A1 | THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-02-19 | — | — | WO | disclosed |
| EP-0072755-B1 | CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC SANTE (FR) | 1985-08-21 | — | — | EP | disclosed |
| US-4496560-A | ACTIVE AGAINST GRAMPOSITIVE BACTERIA | RHONE-POULENC SANTE (FR) | 1985-01-29 | — | — | US | disclosed |
| EP-0072755-A1 | Cephalosporin derivatives, their preparation and pharmaceutical compositions containing them | RHONE-POULENC SANTE (FR) | 1983-02-23 | — | — | EP | disclosed |