Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 14/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1842342 | 0.96 | NSD2 (0.45) | NSD2USP2CYP1A2CLK4LMNA | |
| SCHEMBL1707479 | 0.94 | NSD2 (0.46) | NSD2USP2CYP1A2CLK4LMNA | |
| SCHEMBL1707556 | 0.90 | NSD2 (0.44) | NSD2USP2CYP1A2CLK4LMNA | |
| SCHEMBL1841010 | 0.89 | NSD2 (0.58) | NSD2USP2CYP1A2CLK4LMNA | |
| SCHEMBL2184566 | 0.87 | SLC6A4 (0.40) | CYP1A2LMNAMAPK1CYP2D6ALDH1A1 | |
| SCHEMBL2184357 | 0.85 | EGFR (0.43) | LMNAMAPK1ALDH1A1 | |
| SCHEMBL13536785 | 0.85 | NSD2 (0.45) | NSD2USP2CYP1A2CLK4LMNA | |
| SCHEMBL1843051 | 0.85 | NSD2 (0.56) | NSD2USP2CYP1A2CLK4LMNA | |
| SCHEMBL1706605 | 0.85 | NSD2 (0.40) | NSD2USP2CYP1A2CLK4LMNA | |
| SCHEMBL1841173 | 0.85 | HTT (0.45) | LMNASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841311-B2 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-09-23 | — | — | US | disclosed |
| US-8841311-B2 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-09-23 | — | — | US | disclosed |
| US-8841311-B2 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-09-23 | — | — | US | disclosed |
| EP-2321284-B1 | SULFONE SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNE-MODULATORS FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES | Bayer Pharma AG (DE) | 2012-05-09 | — | — | EP | disclosed |
| US-20110166168-A1 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-07 | — | — | US | disclosed |
| US-20110166168-A1 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-07 | — | — | US | disclosed |
| US-20110166168-A1 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-07 | — | — | US | disclosed |
| EP-2321284-A1 | SULFONE SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNE-MODULATORS FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010009845-A1 | SULFONE SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNE-MODULATORS FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010009845-A1 | SULFONE SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNE-MODULATORS FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166168-A1 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | TPMT, IFNG, HLA-DRB1 | NSD2 1335/4885USP2 3053/4885CYP1A2 384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.