⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6063579 | 0.80 | — | — | |
| SCHEMBL10082608 | 0.76 | AHR (0.50) | — | |
| SCHEMBL10101154 | 0.73 | CRBN (0.42) | — | |
| SCHEMBL14168642 | 0.73 | — | — | |
| SCHEMBL5163446 | 0.70 | — | — | |
| SCHEMBL9951175 | 0.69 | OR51E2 (0.50) | — | |
| SCHEMBL10083526 | 0.69 | CRBN (0.55) | — | |
| SCHEMBL860617 | 0.68 | — | — | |
| SCHEMBL57039 | 0.67 | — | — | |
| Thiazolidinedione SCHEMBL4828229 | 0.67 | GSK3A (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304436-B2 | Pyrazolone derivatives as PDE4 inhibitors | NYCOMED GMBH (DE) | 2012-11-06 | — | — | US | claimed |
| EP-2148876-B1 | PYRAZOLONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2011-09-28 | — | — | EP | claimed |
| US-20100120757-A1 | PYRAZOLONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2010-05-13 | — | — | US | claimed |
| EP-2148876-A1 | PYRAZOLONE DERIVATIVES AS PDE4 INHIBITORS | Nycomed GmbH (DE) | 2010-02-03 | — | — | EP | claimed |
| WO-2008138939-A1 | PYRAZOLONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2008-11-20 | — | — | WO | claimed |
| CN-116057061-A | USP7 inhibitors | 首药控股(北京)股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-114907368-A | USP7 inhibitors | 首药控股(北京)股份有限公司 | 2022-08-16 | — | — | CN | disclosed |
| WO-2022048498-A1 | USP7 INHIBITOR | 首药控股(北京)股份有限公司 | 2022-03-10 | — | — | WO | disclosed |
| US-20200055897-A1 | MODIFIED PEPTOIDS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2020-02-20 | — | — | US | disclosed |
| WO-2016179207-A1 | DEUTERATED FILGOTINIB | CONCERT PHARMACEUTICALS, INC. (US) | 2016-11-10 | — | — | WO | disclosed |
| WO-2016179207-A1 | DEUTERATED FILGOTINIB | CONCERT PHARMACEUTICALS, INC. (US) | 2016-11-10 | — | — | WO | disclosed |
| US-9090597-B2 | Pyrazolone derivatives as PDE4 inhibitors | TAKEDA GMBH (DE) | 2015-07-28 | — | — | US | disclosed |
| US-7192967-B1 | Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents | ASTELLAS PHARMA GMBH (DE) | 2007-03-20 | — | — | US | disclosed |
| EP-1201664-B1 | BENZIMIDAZOLE COMPOUNDS AND DRUGS CONTAINING THE SAME | FUJI PHOTO FILM CO LTD (JP) | 2004-09-08 | — | — | EP | disclosed |
| EP-1042315-B1 | CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2004-04-14 | — | — | EP | disclosed |
| US-6627627-B2 | Useful as psychotherapeutic agents | PFIZER INC. | 2003-09-30 | — | — | US | disclosed |
| US-6593323-B1 | Benzimidazole compound inhibitory action of forming of macrophages and is useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of arteriosclerosis, which is represented by the formula (I): | FUJI PHOTO FILM CO., LTD. (JP) | 2003-07-15 | — | — | US | disclosed |
| EP-1201664-A1 | BENZIMIDAZOLE COMPOUNDS AND DRUGS CONTAINING THE SAME | FUJI PHOTO FILM CO., LTD. (JP) | 2002-05-02 | — | — | EP | disclosed |
| EP-1042315-A1 | CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | Klinge Pharma GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031087-A1 | CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |