SCHEMBL18397

SCHEMBL18397

CC(C)(C)[Si](c1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.36
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 4/20 0.33
TAAR1 Q96RJ0 2/20 0.33
LMNA P02545 2/20 0.33
TSHR P16473 1/20 0.33
ALOX12 P18054 1/20 0.33
ACHE P22303 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
ALOX15 P16050 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29638967 0.97 MAPK1 (0.35) MAPK1KMT2AMEN1ALDH1A1TAAR1
Hydrochloric Acid SCHEMBL22288246 0.97 MAPK1 (0.35) MAPK1KMT2AMEN1ALDH1A1TAAR1
Methoxymethane SCHEMBL28492208 0.92 MAPK1 (0.37) MAPK1KMT2AMEN1ALDH1A1TAAR1
Toluene SCHEMBL28850535 0.90 ACHE (0.52) MAPK1KMT2AMEN1ALDH1A1LMNA
SCHEMBL9850553 0.85 MAPK1 (0.31) MAPK1KMT2AMEN1
SCHEMBL28629156 0.78 ALDH1A1 (0.39) ALDH1A1LMNATSHRTDP1ALOX15
SCHEMBL3691009 0.77 MAPK1 (0.36) MAPK1KMT2AMEN1ALDH1A1TAAR1
SCHEMBL6941189 0.74 MAPK1 (0.35) MAPK1KMT2AALDH1A1TAAR1LMNA
SCHEMBL8933622 0.72 TSHR (0.35) ALDH1A1TAAR1LMNATSHRTDP1
SCHEMBL17529803 0.71 GAA (0.33) ALDH1A1TAAR1ALOX12SLC6A2KCNN4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 39731 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117229145-B Industrial chemical preparation method of 1, 2-diglyceride Guangzhou Baiyunshan Hanfang Modern Pharmaceutical Co.,Ltd. (CN) 2026-05-26 CN claimed
CN-122011012-A (S) -tert-butyl ((2-methyl-7- (trimethylsilyl) hept-6-alkyne-1-yl) oxy) diphenyl silane and synthesis method and application thereof 山东省农业科学院 2026-05-12 CN claimed
CN-121736022-B Preparation method of locked nucleic acid intermediate 北京瑞博奥医药科技有限公司 2026-05-12 CN claimed
US-12559514-B2 Synthesis of fluorinated nucleotides MERCK SHARP & DOHME LLC (US) 2026-02-24 US claimed
CN-116867789-B Preparation method of irinotecan derivative and intermediate thereof 上海复旦张江生物医药股份有限公司 2025-06-24 CN claimed
CN-120157560-A Preparation method of p-chlorotrifluorotoluene 山东道可化学有限公司 2025-06-17 CN claimed
CN-115385926-B Preparation method of linker drug conjugate and intermediate thereof 上海复旦张江生物医药股份有限公司 2025-06-03 CN claimed
CN-119798300-A Synthesis method of alpha condensed ring carbon glycoside and application of alpha condensed ring carbon glycoside in pharmacy 三峡大学 2025-04-11 CN claimed
CN-119661614-A Indolocarbazole glycoside alkaloid, preparation method thereof and application thereof in anti-leukemia drugs 中国海洋大学 2025-03-21 CN claimed
CN-119409666-A Phenyl acrylamide compound and preparation method and application thereof 朗捷睿(苏州)生物科技有限公司 2025-02-11 CN claimed
WO-1983001449-A1 METHOD FOR THE PREPARATION OF INTERMEDIARY COMPOUNDS OF CARBACYCLIN VORBRÜGGEN, Helmut 1983-04-28 WO claimed
US-4356120-A 3-(1-Hydroxyethyl)-4-(but-2-ene)-azetidin-2-one and derivatives MERCK & CO., INC. (US) 1982-10-26 US claimed
WO-1982002202-A1 NOVEL DERIVATIVES OF GUANINE ASTRA LAEKEMEDEL AB (SE) 1982-07-08 WO claimed
EP-0055239-A1 Novel derivatives of guanine Astra Läkemedel Aktiebolag (SE) 1982-06-30 EP claimed
US-4296035-A Total synthesis of the utero-evacuant substance d,l-zoapatanol ORTHO PHARMACEUTICAL CORPORATION (US) 1981-10-20 US claimed
US-4290947-A Process for the preparation of thienamycin and intermediates MERCK & CO., INC. (US) 1981-09-22 US claimed
US-4273709-A Process for the preparation of thienamycin and intermediates MERCK & CO., INC. (US) 1981-06-16 US claimed
EP-0021775-A1 Synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo(3.2.1)octane-1-acetic acid and intermediates ORTHO PHARMACEUTICAL CORPORATION (US) 1981-01-07 EP claimed
US-4237055-A Synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid ORTHO PHARMACEUTICAL CORPORATION (US) 1980-12-02 US claimed
US-4237053-A Total synthesis of the utero-evacuant substance d,l-zoapatanol ORTHO PHARMACEUTICAL CORPORATION (US) 1980-12-02 US claimed