Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13735234 | 0.81 | ALDH1A1 (0.52) | ADRA2CALDH1A1POLBHTTTSHR | |
| SCHEMBL4719206 | 0.80 | ADRA2C (0.59) | ADRA2CALDH1A1POLBHTTLTB4R2 | |
| SCHEMBL7751510 | 0.80 | ADRA2C (0.69) | ADRA2CALDH1A1POLBHTTLTB4R2 | |
| SCHEMBL698882 | 0.80 | ADRA2C (0.64) | ADRA2CALDH1A1POLBHTTLTB4R2 | |
| SCHEMBL1006444 | 0.80 | HTT (0.71) | ADRA2CALDH1A1HTTTSHRMEN1 | |
| SCHEMBL24621887 | 0.80 | ADRA2C (0.59) | ADRA2CALDH1A1POLBHTTLTB4R2 | |
| SCHEMBL4168860 | 0.78 | ADRA2C (0.67) | ADRA2CALDH1A1POLBHTTLTB4R2 | |
| SCHEMBL8332050 | 0.78 | KMT2A (0.71) | ADRA2CALDH1A1HTTLTB4R2TSHR | |
| SCHEMBL6202036 | 0.78 | ADRA2C (0.57) | ADRA2CALDH1A1POLBHTTLTB4R2 | |
| SCHEMBL9614163 | 0.78 | ALDH1A1 (0.48) | ADRA2CALDH1A1POLBHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325462-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | Pharmakea, Inc. (US) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017015221-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-01-26 | — | — | WO | disclosed |