Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28232725 | 0.81 | MEN1 (0.37) | MEN1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL18393416 | 0.81 | MEN1 (0.34) | MEN1KMT2ALMNAMAPT | |
| SCHEMBL28232714 | 0.77 | CDK2 (0.40) | MEN1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL8563511 | 0.75 | MKNK1 (0.36) | MEN1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL31302371 | 0.74 | NPC1 (0.34) | ALDH1A1MAPT | |
| SCHEMBL8560628 | 0.71 | MEN1 (0.35) | MEN1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL5126783 | 0.68 | PKM (0.42) | MEN1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL3688848 | 0.67 | MAPT (0.47) | MEN1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL8561095 | 0.66 | MEN1 (0.42) | MEN1USP2KMT2AKEAP1NFE2L2 | |
| SCHEMBL18486948 | 0.66 | KMT2A (0.42) | MEN1USP2KMT2AKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325451-A1 | FUSED IMIDAZOLES AS MIDH1 INHIBITORS | Bayer Pharma Aktiengesellschaft (DE) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017012967-A1 | FUSED IMIDAZOLES AS MIDH1 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-01-26 | — | — | WO | disclosed |