Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398339 | 0.86 | HRH4 (0.35) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL18398365 | 0.79 | CYP1A2 (0.42) | — | |
| SCHEMBL18398609 | 0.77 | TLR7 (0.32) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398397 | 0.77 | JAK2 (0.49) | JAK2JAK1TYK2JAK3CTSS | |
| SCHEMBL18398362 | 0.76 | GPR6 (0.37) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398568 | 0.73 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398511 | 0.70 | CYP1A2 (0.43) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398229 | 0.69 | JAK2 (0.51) | JAK2JAK1TYK2JAK3CTSS | |
| SCHEMBL18398169 | 0.69 | JAK2 (0.62) | JAK2JAK1TYK2JAK3CTSS | |
| SCHEMBL18398204 | 0.69 | CYP1A2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |